microRNA在肾脏疾病和生理中的研究进展  

Research Progress of MicroRNA in Physiology and Renal Disease

作　　者：晏强[1] 邹耀霜 眭维国[1] 向月应[1] 欧明林[1] 陈洁晶[1] 薛雯[1] 戴勇 

机构地区：[1]解放军第一八一医院肾脏科全军器官移植与透析治疗中心广西代谢性疾病研究重点实验室,广西桂林541002 [2]广西师范大学生命科学学院,广西桂林541004 [3]暨南大学第二临床医学院(深圳市人民医院)临床医学研究中心,广东深圳518020

出　　处：《医学综述》2018年第3期428-433,共6页Medical Recapitulate

基　　金：总后卫生部全军保健专项课题(12BJZ14)

摘　　要：慢性肾脏疾病(CKD)与主要的非传染性疾病(如糖尿病和高血压)密切相关。微RNA(miRNA)是一类内源性有调控作用的非编码RNA,它们在肾脏发育、平衡和疾病中扮演重要角色。特别是在各种CKD的发展中,miRNA的表达与肾小管间质硬化和终末期肾小球病变发生相关。miRNA在基因中具有调控作用,其可能成为肾病的一种新的诊断标志物和治疗靶点。根据现有证据,miRNA可能与糖尿病肾病、IgA肾病、狼疮性肾炎、多囊肾病和移植排斥有关。Chronic kidney disease（ CKD） is closely related to non-communicable diseases such as diabetes and hypertension. MicroRNAs（ miRNAs） are a class of endogenous,non-encoding RNAs that play an important role in kidney development,homeostasis and disease. In particular,the development of various CKD,miRNA expression is closely related to the occurrence of tubulointerstitial sclerosis and terminal glomerular disease. miRNAs have a regulatory role in genes that may become a new diagnostic marker and therapeutic target for nephropathy. Based on available evidence,miRNAs seem to be associated with diabetic nephropathy,IgA nephropathy,lupus nephritis,polycystic nephropathy and graft rejection.

关 键 词：慢性肾脏疾病 微RNA 诊断工具 

分 类 号：R34[医药卫生—基础医学]