探讨BiPAP无创通气在改善中重度慢阻肺稳定期患者运动耐力及肺功能中的效果  

Effect of BiPAP noninvasive ventilation in improving the exercise endurance and pulmonary function of patients with moderate and severe chronic obstructive pulmonary disease at stable stage

作　　者：孙贺鑫 

机构地区：[1]辽阳市中心医院新城医院,111000

出　　处：《中国现代药物应用》2018年第3期14-15,共2页Chinese Journal of Modern Drug Application

摘　　要：目的探讨中重度慢性阻塞性肺疾病(慢阻肺)稳定期患者接受双水平气道正压(Bi PAP)无创通气后运动耐力和肺功能受到的影响,对Bi PAP通气的优势进行分析。方法 148例中重度慢阻肺稳定期患者,随机分成对照组(73例)和观察组(75例)。对照组患者给予鼻导管吸氧治疗,观察组患者给予Bi PAP通气治疗,分析比较两组患者的运动耐力和肺功能。结果治疗前两组6 min步行距离、最长运动时间(Tmax)、最大运动功率(Wmax)、每分钟最大通气量(MVV)、第一秒用力呼气容积占预计值百分比(FEV1%)、残气量(RV)、第一秒用力呼气容积占用力肺活量百分比(FEV1/FVC)比较差异无统计学意义(P>0.05);治疗后观察组6 min步行距离、Tmax、Wmax、MVV、FEV1%、RV、FEV1/FVC均优于对照组,差异具有统计学意义(P<0.05)。观察组治疗成功率94.67%(71/75)、死亡率5.33%(4/75)优于对照组的71.23%(52/73)、28.77%(21/73),差异具有统计学意义(P<0.05)。结论 Bi PAP无创通气治疗对中重度慢阻肺稳定期患者的治疗效果较好,可以改善患者的运动能力与肺功能,临床中可以推广使用。Objective To discuss the effect of bilevel positive airway pressure （BiPAP） noninvasive ventilation in improving the exercise endurance and pulmonary function of patients with moderate and severe chronic obstructive pulmonary disease at stable stage, and analyze the advantages of BiPAP ventilation. Methods A total of 148 patients with moderate and severe chronic obstructive pulmonary disease at stable stage were randomly divided into control group （73 cases） and observation group （75 cases）. The control group was treated with nasal catheter oxygen inhalation, and the observation group was treated with BiPAP ventilation. Exercise endurance and pulmonary function in two groups was analyzed and compared. Results Before treatment, both groups had no statistically significant difference in 6 min walking distance, maximum motion time （Tmax）, maximum work rate （Wmax）, maximum voluntary ventilation （MVV）, forced expiratory volume in 1 second percentage of predicted value （FEV1%）, residual volume （RV）, forced expiratory volume in 1 second / forced vital capacity （FEV1 / FVC） （P〉0.05）. After treatment, the observation group had better 6 min walking distance, Tmax, Wmax, MVV, FEV1%, RV and FEV1 / FVC than the control group, and the difference was statistically significant （P〈0.05）. The observation group had better treatment success rate as 94.67% （71/75） and death rate as 5.33% （4/75） than 71.23% （52/73） and 28.77% （21/73） in the control group, and the difference was statistically significant （P〈0.05）. Conclusion BiPAP noninvasive ventilation shows good treatment effect in treating patients with moderate and severe chronic obstructive pulmonary disease at stable stage, and can improve the exercise endurance and pulmonary function. It can be promoted and used in clinic.

关 键 词：双水平气道正压无创通气 慢性阻塞性肺疾病 运动耐力 肺功能 

分 类 号：R563.9[医药卫生—呼吸系统]