Flotillin-1的生理功能及其在疾病中的作用研究进展  

Advances in Study of Physiological Function of Flotillins and its Role in Disease

作　　者：王旭研 张叶军[1] 李洪艳[1] 崔玉影[1] 张炳强[2] 邹伟[1,2] 

机构地区：[1]辽宁师范大学生命科学学院,辽宁大连116000 [2]卫生部细胞移植重点实验室青岛瑞思德生物科技有限公司,山东青岛266000

出　　处：《生物技术通讯》2018年第1期105-108,共4页Letters in Biotechnology

基　　金：国家自然科学基金(30970353);辽宁省科技计划(2015020568)

摘　　要：Flotillin-1(浮舰蛋白-1)是脂筏的标记蛋白。它不但参与多种细胞正常的生理活动,也在许多肿瘤发生和发展中起重要作用。近年发现Flotillin-1在肺腺癌、乳腺癌、肝细胞癌等细胞中高表达,并与临床等级、预后差、总体存活率低有关联。简要综述了Flotillin的组成、结构和基本功能,以及在疾病中的作用。Flotillin-1 is a marker protein of lipid raft. It is not only involved in a variety of normal physiological activities of cells, but also plays an important role in many tumorigenesis and development. Recently, it has been found that flotillin-1 is highly expressed in lung adenocarcinoma, breast cancer and hepatocellular carcinoma cells, and associated with clinical grade, poor clinical grade and low overall survival. We reviewed the composition, structure, and basic functions of flotillins as well as the role in the disease.

关 键 词：Flotillin-1 脂筏 疾病 

分 类 号：Q291[生物学—细胞生物学]