复方黄连膏中雄黄的质量控制  

Quality Control of Realgar in Compound Huanglian Ointment

作　　者：曾祖平 李彧[2] 谭征 韩旭阳 彭冰 王宏 何薇 

机构地区：[1]首都医科大学附属北京中医医院北京市中医研究所银屑病中医临床基础研究北京市重点实验室,北京100010 [2]天津医科大学临床医学院,天津300270 [3]北京首儿药厂,北京101304

出　　处：《中国中医药信息杂志》2018年第3期68-71,共4页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：北京中医药科技发展资金项目(JJ2016-03)

摘　　要：目的控制复方黄连膏中雄黄的质量。方法对雄黄中毒性成分三氧化二砷采用古蔡氏法进行限度检查;对雄黄主要成分二硫化二砷利用硫酸钾、硫酸铵和硫酸消解后采用滴定法进行定量分析。结果复方黄连膏中可溶性砷含量不高于15.6μg/g,二硫化二砷含量不低于2.21 mg/g。结论本方法简便易行,可以有效控制制剂中雄黄的质量。Objective To control the quality of realgar in compound Huanglian Ointment. Methods As2O3 which is the toxic component of realgar was carried limit test by Gutzeit＇s test; Potassium sulfate, ammonium sulfate and sulfuric acid were used to digest, and then titration method was used to determine the content of As2S2 in compound Huanglian Ointment. Results The content of the soluble As in compound Huanglian Ointment was no higher than 15.6 μg/g. The content of As2S2 in compound Huanglian Ointment was no less than 2.21 mg/g. Conclusion The method is simple and easy, which can be applied as the quantity control method of compound Huanglian Ointment.

关 键 词：复方黄连膏 雄黄 三氧化二砷 二硫化二砷 

分 类 号：R284.1[医药卫生—中药学]