江苏省2009—2016年预防接种后免疫性血小板减少症监测分析  

Analysis of immune thrombocytopenia after vaccination in Jiangsu province from 2009 to 2016

作　　者：高君[1] 汤奋扬[1] 张晋琳[1] 周明浩[1] 汪志国[1] 康国栋[1] 胡冉 

机构地区：[1]江苏省疾病预防控制中心,江苏南京210009

出　　处：《江苏预防医学》2018年第1期34-37,共4页Jiangsu Journal of Preventive Medicine

基　　金：江苏省重大新发传染病综合防控科技示范工程(BE2015714)

摘　　要：目的分析江苏省预防接种后免疫性血小板减少症(ITP)的发生特征,评价预防接种后ITP的发生风险。方法通过疑似预防接种异常反应(AEFI)信息管理系统,收集截至2017年3月10日报告的2009—2016年预防接种后ITP个案数据,采用描述流行病方法进行分析。结果江苏省2009—2016年共报告预防接种后ITP个案65例,报告发生率为0.32/100万剂;年龄以<1岁组为主(占72.31%);男女比为1.95∶1;以4—6月报告例数最多。预防接种后ITP个案涉及19种疫苗,各疫苗报告发生率在0.11/100万剂~9.33/100万剂。65例个案中,最终调查诊断为异常反应30例(占46.15%)、偶合症35例(占53.85%)。结论江苏省疫苗预防接种后ITP报告发生率低于世界卫生组织估算的预期发生率。预防接种后ITP属于严重AEFI,调查诊断需加强因果关联评估。Objective To analyze the occurrence features of immune thrombocytopenia（ITP）as adverse event following immunization（AEFI）in Jiangsu province;to evaluate the occurrence risk of ITP after vaccination.Methods Surveillance data of ITP after vaccination from 2009 to 2016 were collected through the national AEFI information management system,which were reported before Mar 10 th,2017.The descriptive epidemiological analysis was used in the study.Results A total of 65 ITP cases after vaccination were reported from 2009 to 2016,the average incidence was 0.32 per 1 000 000 doses.Children aged less than l year old accounted for 72.31%,and the male-to-female ratio was 1.95∶1.ITP cases were reported mainly from Apr to Jun.A total of 19 kinds of vaccines were involved,with a range of 0.11 per 1000 000 doses to 9.33 per 1000 000 doses for the reporting incidence.Among the 65 ITP cases,30 cases（46.15%）were finally diagnosed as rare vaccine reaction and 35 cases（53.85%）were coincidental events.Conclusion The incidence of ITP after vaccination from 2009 to 2016 in Jiangsu Province was lower than the expected rate by WHO.ITP after vaccination was serious AEFI,and it is necessary to improve the quality of the causality assessment to determine the likelihood of a causal association between ITP and the vaccine received.

关 键 词：疑似预防接种异常反应 免疫性血小板减少症 监测 

分 类 号：R558[医药卫生—血液循环系统疾病]