细胞膜片技术在骨与软骨组织工程领域的研究进展  

Application of cell sheet technology in bone and cartilage tissue engineering

作　　者：支振亚 邢飞[1] 陈龙[1] 李浪[1] 龙也[1] 项舟[1] 

机构地区：[1]四川大学华西医院骨科,成都610041

出　　处：《中国修复重建外科杂志》2018年第2期237-241,共5页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家自然科学基金资助项目(31370984)~~

摘　　要：目的对细胞膜片技术在骨与软骨组织工程修复领域的研究进展进行综述。方法广泛查阅近年应用细胞膜片技术进行骨与软骨修复重建的相关文献,归纳总结后进行综述。结果通过多种不同方法构建出的细胞膜片有效地保护了细胞外基质。细胞膜片通过自身折叠、包被相应生物材料以及不同膜片间叠加等方式,在骨与软骨组织修复中展现出了良好的修复效果。结论细胞膜片技术作为骨与软骨组织工程领域一种新的治疗策略具有广阔应用前景。Objective To review the progress ofcell sheet technology and its application in bone and cartilage engineering. Methods The recent literature concerning the cell sheet technology used in treatment of bone and cartilage defects was extensively reviewed and summarized. Results Cell sheet built through many different ways can protect extracellular matrix from proteolytic enzymes. As a three-dimensional structure, cell sheet can repair bone and cartilige defects via folding, wrapping scaffold, or be created by the layering of individual ceU sheets. Conclusion The cellsheet technology would have a very broad prospects in bone and cartilage tissue engineering in future.

关 键 词：细胞膜片技术 骨组织工程 软骨组织工程 

分 类 号：R318.08[医药卫生—生物医学工程]