民航飞行员空腹血糖水平与冠状动脉易损斑块的相关性研究  

Study on correlationship between fasting blood glucose level and coronary arterial vulnerable plaque in civil airline pilots

作　　者：樊泽元 季汉华 

机构地区：[1]民航总医院心内科,北京100025

出　　处：《重庆医学》2018年第5期647-649,653,共4页Chongqing medicine

摘　　要：目的探讨民航飞行员空腹血糖(FBG)水平与冠状动脉(以下简称冠脉)易损斑块关系,以及易损斑块的危险因素。方法将120例民航飞行员冠心病患者根据虚拟组织学血管内超声(VH-IVUS)检查结果,分为非易损斑块组(对照组)和易损斑块组(观察组),收集其临床资料,并应用Logistic回归分析易损斑块的危险因素。结果与对照组比较,观察组民航飞行员FBG水平更高(P<0.05);FBG与超敏C反应蛋白(hs-CRP)、低密度脂蛋白(LDL)均是易损斑块的危险因素;FBG水平与斑块坏死核心构成比呈正相关(r=0.44,P<0.05);ROC曲线诊断易损斑块效率的曲线下面积(AUC)为0.72(95%CI:0.66~0.81),当FBG切值取6.39时,敏感性为71.35%,特异性为76.15%。结论 FBG水平是冠脉易损斑块的独立危险因素,可辅助民航飞行员易损斑块识别。Objective To investigate the relationship between fasting blood glucose（FBG） with coronary arterial vulnerable plaquein civil airline pilots and its risk factors. Methods One hundred and twenty civil airline pilots with coronary heart disease were divided into the vulnerable plaque group and non-vulnerable plaque group based on the virtual histology intravascular ultra- sound（VH-IVUS） results. Then the clinical data were collected. Logistic regression analysis was used to analyze the risk factors of vulnerable plaque. Results The FBG level in the vulnerable plaque group was much higher（P〈0.05） ;FI3G,high-sensitivity C-re- active protein and low density lipoprotein were the risk factors for vulnerable plaque;FBG was positively correlated with the plaque necrosis core constituent ratio（r=0.44,P〈0.05）. The area under curve of ROC curve efficiency for diagnosing vulnerable plaque was 0. 72（95%CI：0. 66--0. 81） ,at FBG cut-off value of 6.39 ,the sensitivity was 71.35%and specificity was 76.15%. Conclusion .The FBG level is an independent risk factor of coronary arterial vulnerable plaque,which can assist in the identification of vulner- able plaque in civil airline pilots.

关 键 词：民航飞行员 空腹血糖 冠心病 易损斑块 

分 类 号：R541.4[医药卫生—心血管疾病]