西吡氯铵含漱液与西帕依固龈液联合使用对口腔假丝酵母感染治疗的研究  

Effect of cetylpyridinium chloride gargle combined with xipayimouth rinse on treatment of oral Candidainfections

作　　者：高永博[1] 洪滔[1] 何欣[1] 胡新兰[1] 张倩 GAO Yong-bo;HONG Tao;HE Xin;HU Xin-lan;ZHANG Qian(Hangzhou Red Cross Hospital, Hangzhou , Zhejiang 310000, China)

机构地区：[1]杭州市红十字会医院口腔科,浙江杭州310000

出　　处：《中华医院感染学杂志》2018年第3期444-447,共4页Chinese Journal of Nosocomiology

基　　金：2011年浙江省医药卫生基金资助项目(2011KYB075)

摘　　要：目的研究含漱西吡氯铵对口腔假丝酵母感染患者的治疗效果和西吡氯铵与西帕依固龈液联合使用对口腔假丝酵母菌感染患者的治疗效果。方法选取2014年12月-2016年12月在医院接受治疗的口腔假丝酵母感染患者225例,分为试验组113例和对照组112例,试验组采用西吡氯铵与西帕依固龈液联合使用,对照组采用含漱西吡氯铵;观察两组患者治疗前后临床症状的改善情况、红斑黏膜和口腔疼痛评分的改善情况及患者经治疗后的疗效。结果治疗后,两组患者口腔真菌清除效果,差异无统计学意义;治疗后,试验组红斑黏膜评分和口腔疼痛评分分别为(0.45±0.12)分和(0.44±0.17)分低于对照组(0.91±0.19)分和(0.95±0.21)分,两组红斑黏膜评分和口腔疼痛评分比治疗前降低(P均<0.05)。两组菌落数均减少,但差异无统计学意义;两组患者口腔真菌清除效果,差异无统计学意义。结论西吡氯铵与西帕依固龈液联合使用在一定程度可有效清除口腔假丝酵母,改善患者临床症状,缓解患者痛苦。OBJECTIVE To investigate the effects of cetylpyridinium chloride gargle and combination of cetylpyri- dinium chloride and xipayimouth rinse on oral Candida infections. METHODS A total of 225 patients with oral Candida infections treated in the hospital from Dec. 2014 to Dec. 2016 were selected, the patients were randomly divided into experimental group of 113 cases and control group of 112 cases. Patients in experimental group were treated with combination of cetylpyridinium chloride and xipayimouth rinse, and in control group were treated with cetylpyridinium chloride gargle. The improvement of clinical symptoms, the improvement of the scores of er- ythema, mucous membrane and oral pain and the total effective rate of the patients after treatment were observed in the two groups.RESULTS After treatment, the total effective rates of the two groups had no significant differ- ence. After treatment, erythematous mucosa score and oral pain score of experimental group were （0.45 ±0.12） and （0.44±0.17）, which were lower than （0.91±0.19） and （0.95±0.21） of control group, and the erythematous mucosa score and pain score of oral mucosa of the two groups were significantly decreased compared with those before treatment （P〈0.05）. The number of colonies in the two groups were decreased, but the difference was not significant. CONCLUSION The combination of cetylpyridinium chloride and xipayimouth rinse can effectively re- move Candida to a certain extent, improve clinical symptoms, and improve patient outcomes.

关 键 词：西吡氯铵 西帕依固龈液 口腔假丝酵母 

分 类 号：R379[医药卫生—病原生物学]