葛根总黄酮在聚醚砜超滤膜上的吸附与解吸方法的探讨  

Study on Adsorption and Desorption of Total Flavonoids from Pueraria lobata( Willd. ) Ohwi on Polyethersulfone Ultrafiltration Membrane

作　　者：樊文玲 徐艳[2,3] 张心怡[2,3] FAN Wenling;XU Yan;ZHANG Xinyi(Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing 210023 ,Jiangsu, China;Pharmacy College, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China;Jiangsu Engineering Research Center for Efficient Delivery System of Traditional Chinese Medicine, Nanjing 210023, Jiangsu, China)

机构地区：[1]江苏省中药资源产业化过程协同创新中心,江苏南京210023 [2]南京中医药大学药学院,江苏南京210023 [3]江苏省中药高效给药系统工程技术研究中心,江苏南京210023

出　　处：《中华中医药学刊》2018年第2期344-347,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(30801552,81274095);江苏省中药资源产业化过程协同创新中心第三批立项重点项目(012092002006-10);南京中医药大学第55批博士后项目(021062001001)

摘　　要：目的：考察葛根总黄酮在超滤膜聚醚砜（PES）上的等温吸附模型以及解吸方法。方法：将PES超滤膜浸没在不同浓度的葛根总黄酮溶液中进行吸附,考察初始浓度与膜吸附量的关系,并进行吸附模型的拟合。选用不同浓度的氢氧化钠和乙醇溶液作为解吸液,以解吸率和膜水通量为指标,选择最佳的解吸液。结果：PES超滤膜上葛根总黄酮的吸附符合Langmuir等温式,氢氧化钠溶液可作为解吸液,且浓度为0.075 mol/L时的解吸效果最佳。结论：建立了葛根总黄酮在PES超滤膜上的吸附等温方程和对应的解吸方法,为膜材料在中药精制过程中吸附的中药活性成分的资源化回收提供了理论依据。Objective： To explore the isothermal adsorption model and desorption method by studying total flavonoids from Pueraria lobata （Willd.） Ohwi in the uhrafiltration membrane polyether sulfone （PES）. Methods： PES membranes were immersed in different concentrations of total flavonoids from Pueraria lobata （ Willd. ） Ohwi solution for adsorption, and the relationship between concentration and the amount of adsorption was studied. The adsorption model was fitted ac- cording to the data. Further, desorption methods were performed by using different desorption solutions according to de- sorption rate and water flux of the membrane, and the optimum desorption solution was selected. Results ： Total flavonoids from Pueraria lobata （ Willd. ） OhM in the PES membrane was in accordance with the Langmuir isotherm and desorption of 0. 075 mol/L sodium hydroxide solution was the best. Conclusion： The adsorption isotherm equation and the corre- sponding desorption method of total flavonoids from Pueraria lobata （ Willd. ） Ohwi in the PES membrane was stablished, which provided a theoretical basis for resource recovery of active ingredients of traditional Chinese medicine adsorbed in traditional Chinese medicine refining process.

关 键 词：聚醚砜 葛根总黄酮 吸附 解吸 

分 类 号：R284.1[医药卫生—中药学]