过敏煎联合孟鲁司特钠对咳嗽变异性哮喘患儿肺功能影响的研究  

Influence of Self-made Guominjian Combined with Montelukaston Pulmonary Function in Children with Cough Variant Asthma

作　　者：李璟[1] 吴春红 刘丽[2] LI Jing;WU Chunhong;LIU Li(Pediatric Department, Jiaxing Maternal and Child Health- Care Center,Jiaxing 314051 ,Zhejiang, China;Jiaxing Maternal and Child Health - Care Center,Jiaxing 314051 ,Zhejiang,China)

机构地区：[1]嘉兴市妇幼保健院儿科,浙江嘉兴314051 [2]嘉兴市妇幼保健院中医儿科,浙江嘉兴314051

出　　处：《中华中医药学刊》2018年第2期499-501,共3页Chinese Archives of Traditional Chinese Medicine

摘　　要：目的：研究自拟过敏煎联合孟鲁司特钠对咳嗽变异性哮喘患儿肺功能的影响。方法：选择120例咳嗽变异性哮喘患儿作为研究对象,采用SPSS 22.0软件进行计算机随机化,将患者1∶1分为两组,对照组患儿给予孟鲁司特钠口服,治疗组在对照组治疗的基础上加用自拟过敏煎,药物组成：黄芪15 g,炒白术10 g,党参12 g,百部9 g,北沙参10 g,麦冬10 g,桑白皮9 g,防风10 g,紫菀9 g,蝉衣6 g,柴胡9 g,乌梅6 g,五味子5 g,炙甘草6g。疗程共3个月。比较治疗前后两组患儿的临床疗效、咳嗽评分及肺功能指标的变化。结果：治疗后,两组患儿临床疗效相比差异无统计学意义（P〉0.05）,咳嗽评分、PEF及FVC相比差异具有统计学意义（P〈0.05）,FEV_（1.0）、FEV_（1.0）/FVC相比差异具有显著统计学意义（P〈0.001）。治疗前后两组患儿肺功能各指标组内比较差异均具有显著差异（P〈0.001）。结论：两种方法治疗儿童咳嗽变异性哮喘均有效,都可以改善患儿的肺功能,但是自拟过敏煎联合孟鲁司特钠在减轻患儿咳嗽症状、改善肺功能方面的效果比单用孟鲁司特更好。Objective ： To observe the effect of self - made Guominjian combined with comontelukast sodium on pulmo- nary function in children with cough variant asthma. Methods： In this study, 120 cases of CVA were selected. The pa- tients were randomly divided into treating group and control group, using SPSS 22.0 software for computer randomization, 60 cases in each group. The control group was given montelukast and the treating group used self- made Guominjian on the basis of control group. The two groups were treated for 3 months. The clinical efficacy, cough scores and changes in pulmonary function were compared before and after treatment. Result： After treatment, the difference of clinical efficacy between the two groups had no statistical significance（P 〉0. 05）. The difference of cough scores, PEF and FVC had sta- tistical significance （ P 〈 0. 05 ）. FEV1.0 abd FEV1.0/FVC had a significant difference （P 〈 0. 001 ）. Compared within groups, there were significant differences in pulmonary function in the two groups before and after treatment （ P 〈 0. 001 ）. Conclusion： Two therapies treating children with cough variant asthma are comparable and can improve puImonary func- tion, but in reducing cough symptoms and improving pulmonary function using self - made Guominjian combined with montelukast is better than montelukast.

关 键 词：过敏煎 孟鲁司特 咳嗽变异性哮喘 儿童 肺功能 

分 类 号：R256.12[医药卫生—中医内科学]