2158例深部真菌感染拟诊病例临床特点与病原菌检查  

Clinical features and pethageon detect of 2 158 cases of deep fungal infection

作　　者：强明月 王开琴 李红宾[1] 黄云丽[1] 董天祥[1] 李玉叶[1] 

机构地区：[1]昆明医科大学第一附属医院皮肤科,云南昆明650031

出　　处：《皮肤病与性病》2018年第1期3-6,共4页Dermatology and Venereology

基　　金：云南省应用基础研究面上项目(2014FB030);国家自然科学基金地区基金项目(81560325);国家自然科学基金地区基金项目(81660248)

摘　　要：目的总结分析送检拟诊深部真菌感染病例临床特征和实验室结果,为临床更好的诊治深部真菌感染提供借鉴。方法回顾性分析我院(2012~2016)年真菌室深部真菌送检病例临床资料和真菌检查结果。结果 2 158例送检标本中,镜检查出菌丝和/或孢子的阳性标本共336例,镜检阳性率为15.57%,培养阳性标本共496例,培养阳性率为22.89%;鉴定出白假丝酵母菌406株(82.19%),光滑假丝酵母菌48株(9.72%),其他真菌的比例不足10%。深部真菌感染的部位主要为口腔,占26.91%;光滑假丝酵母菌和新型隐球菌感染更易发生在(31～40)岁年龄组;热带假丝酵母菌感染则易发生于(41～50)年龄段和71岁以上年龄段。不同年龄段真菌培养结果有统计学差异。结论深部真菌感染的主要病原菌为白假丝酵母菌,但光滑假丝酵母菌等非白假丝酵母菌的检出率逐年增高,各菌种在不同年龄段分布存在差异。Objective Analyzed cases of deep fungal diseases examinated in fungal lab, to understand more about clinical features and treatment of the disease. Methods A retrospective analysis was carried out. Results Among 2 158 samples, 336 cases were microscopic examination positive, accounting for 15.57%, and the culture positive rate was 22.89%. The 406 strains of Candida albicans （82.19%）, 48 strains of Candida glabrata （9.72%） were identified, and the proportion of other fimgi was less than 10%. Oral is the main parts of deep fungal infection, accounting for 26.91% of all . Candida glabrata and Cryptococcus neoformans infections are more likely to occur in the 31 -40 age group; Candida tropicalis infections mainly occur in old people. Statistical difference of fungal culture results was seen in different age groups. Conclusion Candidia species are the main pathogen, while Candidia glabrata infection is increasing. The differences of fungal strains distribution in different age groups is significant.

关 键 词：深部真菌感染 临床特点 病原菌 检测 

分 类 号：R756.6[医药卫生—皮肤病学与性病学] R519.3[医药卫生—临床医学]