宫颈癌^(18)F-FDG PET/CT标准化摄取值与血管内皮生长因子、水通道蛋白1表达及临床病理特征的相关性  

Correlations of ^(18)F-FDG PET/CT standardized uptake value,vascular endothelial growth factor,Aquaporin-1 level and clinicopathological features of cervical cancer

作　　者：张乐[1,2] 孙洪赞 辛军[1] 杜思瑶[1] 张立欧 李可心 

机构地区：[1]中国医科大学附属盛京医院放射科,辽宁沈阳110004 [2]辽宁省医学影像重点实验室,辽宁沈阳110004

出　　处：《中国医学影像技术》2018年第2期260-264,共5页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金青年科学基金(81401438);辽宁省教育厅科学研究一般项目(L2014308);辽宁省教育厅重点实验室基础研究项目(LZ2015079)

摘　　要：目的探讨宫颈癌^(18 )F-FDG PET/CT标准化摄取值(SUV)与血管内皮生长因子(VEGF)、水通道蛋白-1(AQP-1)表达水平及临床病理特征之间的相关性。方法回顾性分析56例宫颈癌患者术前PET/CT影像资料,测量肿瘤平均标准化摄取值(SUV_(mean))、最大标准化摄取值(SUV_(max))及标准化摄取值峰值(SUV_(peak))。应用免疫组织化学方法检测宫颈癌组织的VEGF、AQP-1表达水平,分析SUV值与VEGF、AQP-1表达水平及临床病理特征间的相关性。结果国际妇产科联合会(FIGO)不同分期间SUV_(mean)、SUV_(peak)、VEGF、AQP-1表达水平差异均有统计学意义(P均<0.05);肿瘤最大径≥4cm者SUV_(peak)和VEGF表达水平均高于最大径<4cm者(P均<0.05);浸润深度≥1/2宫颈肌壁者SUV_(peak)、VEGF和AQP-1表达水平均高于浸润深度<1/2宫颈肌壁者(P均<0.05);有淋巴结转移者VEGF和AQP-1表达水平均高于无淋巴结转移者(P均<0.05)。SUV_(peak)与VEGF(r_s=0.529,P<0.001)、AQP-1(r_s=0.356,P=0.007)表达水平的相关性相对较高。结论宫颈癌术前PET/CT SUV_(peak)值与临床病理特征有相关性,可用于指导制定宫颈癌个体化治疗方案。Objective To explore the correlations among standardized uptake value （SUV） and clinicopathological features of cervical cancers, and to observe the association among SUV and expression level of vascular endothelial growth factor （VEGF） and Aquaporin-1 （AQP-1）. Methods PET/CT imaging data were analyzed retrospectively in 56 patients with cervical cancer before surgery. The mean SUV （SUV ）, maximum SUV （SUVMAx） and peak SUV （SUVpeak） were measured, and immunohistochemical method was used to detect the expression of VEGF and AQP-1. The relationships of SUV and expression level of VEGF, AQP-1 and clinicopatho[ogical features were analyzed. Results SUV SUVpEAK and expression level of VEGF and AQP-1 were significantly different in different FIGO stages （all P G0.05）. SUVPEAK and expression level of VEGF in tumors with maximum diameter ~ 4 cm were higher than those in patients with tumors maximum diameter G4 cm （both P G0.05）. SUVpEAk and expression level of VEGF and AQP-1 in tumors with cervical stromal invasion depth ≥1/2 were significantly higher than those with cervical stromal invasion depth G 1/2 （all P〈0.05） . The expression level of VEGF and AQP-1 in patients with lymph node metastasis were higher than those without lymph node metastasis （both P G0.05）. SUVpeak was correlated with expression level of VEGF （r1 =0. 529, P〈0. 001） and AQP-1 （r2 = 0. 356, P = 0. 007）. Conclusion Preoperative SUVpEAk of cervical cancer measured with PET/CT is correlated with clinicopathological features and can be used to guide individual treatment of patients with cervical cancer.

关 键 词：宫颈肿瘤 正电子发射型体层摄影术 体层摄影术 x线计算机 血管内皮生长因子 水通道蛋白-1 

分 类 号：R817.4[医药卫生—影像医学与核医学] R737.33[医药卫生—放射医学]