功能磁共振成像在胶质瘤精确诊断中的研究  

Functional magnetic resonance imaging in the accurate diagnosis of gliomas

作　　者：王巍[1] 孙鹏[1] 刘妍姝[1] 李露露[1] 刘志兰[1] 张原理 张毓婧[1] WANG Wei;SUN Peng;LIU Yanshu;Ll Lulu;LIU Zhilan;ZHANG Yuanli;ZHANG Yujing(Department of MRI,The First Affiliated Hospital of Harbin Medical University, Harbin 150001 ,China)

机构地区：[1]哈尔滨医科大学附属第一医院磁共振室,哈尔滨150001

出　　处：《实用肿瘤学杂志》2017年第6期524-527,共4页Practical Oncology Journal

基　　金：黑龙江省教育厅科学技术研究项目(12531244)

摘　　要：目的应用多种功能磁共振成像对胶质瘤进行评估,术前对脑胶质瘤进行较精准的诊断。方法收集35例经病理诊断证实的胶质瘤患者,均行常规磁共振成像(Magnetic resonance imaging,MRI)及功能MRI检查,对体素内不相干运动扩散加权成像(Intravoxel incoherent motion diffusion weighted imaging,IVIM-DWI)中快速扩散系数(D*)、慢扩散系数(D)、灌注分数(f)和分布扩散系数(DDC)的值进行统计学分析。结果高级别胶质瘤患者病灶侧IVIM的D、D*、DDC值较对侧正常脑白质增高(D:0.71±0.05×10^(-3)mm^2/s vs.0.14±0.03×10^(-3)mm^2/s;D*:0.06±0.04 mm^2/s vs.0.03±0.02 mm^2/s;DDC:1.29±0.33×10^(-3)mm^2/s vs.0.43±0.14×10^(-3)mm^2/s)、f值较对侧正常脑白质降低(f:0.41±0.11vs.0.51±0.05),差异均具有统计学意义(P<0.05)。结论多种磁共振功能成像序列协同分析胶质瘤,可以避免肿瘤的异质性,显著提高了磁共振检查对高级别脑胶质瘤实性部分的识别能力及精确性。Objective The aim of this study was to evaluate the glioma using the variety of functional magnetic resonance imaging（f MRI）,and to perform a more accurate preoperative diagnosis of gliomas.Methods Thirty-five patients with gliomas confirmed by pathology were examined by magnetic resonance imaging（MRI）and functional MRI.Rapid diffusion coefficient（D＊）,Slow diffusion coefficient（D）,perfusion fraction（f）and distribution diffusion coefficient（DDC）in the intravoxel incoherent motion diffusion weighted imaging（IVIM-DWI）were analyzed statistically.ResultsThe mean values of D＊,D,f and DDC in the IVIM sequence of the patients with high-grade of gliomas were statistically significant when compared to the IVIM values of the contralateral normal brain tissues（P0.05）.Conclusion A variety of magnetic resonance functional imaging sequences are used to analyze gliomas,which can avoid tumor heterogeneity and improve the recognition ability and accuracy of magnetic resonance imaging in high grade gliomas.

关 键 词：胶质瘤 磁共振成像 体素内不相干运动 三维增强梯度回波T2＊血管成像序列 动脉自旋标记灌注成像 

分 类 号：R445.2[医药卫生—影像医学与核医学]