前列地尔对慢性肾病患者对比剂肾病的抗氧化应激作用  

Effects of alprostadil on oxidative stress in contrast-induced nephropathy in patients with chronic kidney disease

作　　者：梅百强[1] 杨希立[1] 许兆延[1] 岑锦明[1] 周昭嵛 李健民[1] 李健[1] 李洁源 何彩勤 唐少梅 

机构地区：[1]中山大学附属佛山市第一人民医院心内科,广东佛山528000

出　　处：《实用放射学杂志》2018年第2期274-277,共4页Journal of Practical Radiology

基　　金：佛山市医学类科技攻关项目（2015AB00280）.

摘　　要：目的 探讨前列地尔对慢性肾病（CKD）患者行冠状动脉介入治疗（PCI）后对比剂肾病（CIN）的抗氧化应激作用。方法 前瞻性入选本院拟行PCI的CKD患者200例，按照随机数字表法分为前列地尔组100例，常规治疗组100例。观察2组患者术前和术后72 h及7 d的血清肌酐（Scr）、肌酐清除率（eGFR）、血清胱抑素C（ScysC）、8-羟基脱氧鸟嘌呤（8-OHdG）的水平变化情况。结果 前列地尔组PCI术后CIN发生率明显低于常规治疗组（6% vs 12%，P＜0.05）。前列地尔组与常规治疗组Scr、eGFR、ScysC、8-OHdG水平比较，其术前基线水平无差异（P＞0.05）；前列地尔组术后72 h及7 d的Scr水平明显低于常规治疗组， eGFR水平明显高于常规治疗组（P＜0.05）；2组患者术后72 h及7 d的ScysC、8-OHdG水平较术前均明显升高（P＞0.05），前列地尔组PCI术后72 h及7 d的ScysC、8-OHdG水平明显低于常规治疗组（P＜0.05）。结论 前列地尔可改善行PCI的CKD患者的氧化应激状态，对CIN可能有一定的预防作用。Objective To investigate the anti-oxidative effects of alprostadil on contrast-induced nephropathy （CIN） after percnteous coronary intervention （PCI） in patients with chronic kidney disease（CKD）.Methods A total of 200 patients with CKD were enrolled in our hospital. According to the random number table was divided into alprostadil 100 cases, 100 cases of conventional treatment group.The levels of serum ereatinine （Scr）, creatinine clearance （eGFR）, serum cystatin C （SeysC） and 8-hydroxy-deoxyguanine （8-OHdG） were observed before and after operation at 72 h and 7 d after operation.Results The incidence of CIN in the alprostadil group was significantly lower than that in the conventional treatment group （6% vs 12%, P（0.05）.There was no significant difference in the level of Scr, eGFR, ScysC and 8-OHdG between the alprostadil group and the conventional treatment group （P〉0.05）.The level of Ser in the alprostadil group was significantly lower than that in the conventional treatment group at 72 h and 7 d after operation. The level of eGFR was significantly higher than that of the conventional treatment group （P 〈0.05）. The levels of SeysC and 8-OHdG in the two groups were significantly higher than those before operation at 72 h and 7 d （P〉0.05）. The levels of ScysC and 8-OHdG in the alprostadil group were significantly lower than those in the conventional treatment group at 72 h and 7 d after PCI （P〈0.05）.Condusion Alprostadil may improve the oxidative stress in patients with CKD and provide a preventive effect on CIN.

关 键 词：前列地尔 慢性肾病 对比剂肾病 氧化应激 

分 类 号：R983[医药卫生—药品] R815[医药卫生—药学]