透明质酸抑制炎症因子表达对预防妇科腹腔镜手术盆腔黏连影响  

Effects of hyaluronic acid on prevention pelvic adhesions of abdominal surgery via inhibiting inflammatory factors

作　　者：高丽娟 理习阳[1] 胡雪霁 周容[1] Gao Li-juan;Li Xi-yang;Hu Xue-ji;Zhou Rong(Department of Obstetrics and Gynecology, Traditional Chinese Medicine Hospital of Luzhou, Sichuan Luzhou 64600)

机构地区：[1]泸州市中医医院妇产科,四川泸州646000

出　　处：《四川生理科学杂志》2017年第4期200-202,共3页Sichuan Journal of Physiological Sciences

摘　　要：目的:观察妇科手术腹腔退镜前给予透明质酸对患者炎症因子表达影响及防止盆腔黏连的预防效果。方法:选取我院2015年~2016年接受腹腔镜下妇科手术患者100例,随机分为透明质酸组与对照组,每组50人。两组均行常规腹腔镜下盆腔手术治疗,对照组腹腔手术后常规退镜,透明质酸组腹腔手术结束退镜前取透明质酸10ml涂抹于病灶处;收集患者术前24h以及术后24h血液,通过ELISA法检测两组手术前、后炎症因子IL-6、TNF-α的水平;检测血液流变学指标改变,并通过B超观察两组患者术后3月的黏连情况及黏连率。结果:术后透明质酸组IL-6、TNF-α水平均低于对照组(P<0.05);术后透明质酸组全血黏度、全血还原黏度、血细胞比容、血浆黏度均低于对照组(P<0.05);透明质酸组术后3月发生黏连率低于对照组(P<0.05)。结论:妇科腹腔镜手术完成前给予透明质酸能有效防治盆腔黏连,可能与抑制机体炎症因子表达有关。Objective：To investigate the effects of hyaluronic acid on prevention pelvic adhesions in gynecologic surgery via inhibiting inflammatory factors.Methods：One hundred cases of patients who carried out the gynecologic surgery with Laparoscopic in our hospital from 2015-2016 were included in this study.All the patients were divided into the hyaluronic acid group and control group randomly（n=50）.Ten ml hyaluronic acid was smeared on the lesion of the patients before abdominal closure in the hyaluronic acid group.Blood sample of patients with preoperative 24 hours and postoperative 24 hours were collected,the levels of IL-6 and TNF-αwere observed by ELISA;hemorheological indexes were observed,and the adhesion rate were observed by B-ultrasonography in the third month after surgery.Results：Compared the control group,the levels of IL-6 and TNF-αin the hyaluronic acid group were significantly decreased in the hyaluronic acid group（P〈0.05）.The whole blood viscosity,whole blood reduction viscosity,hematocrit and plasma viscosity of the hyaluronic acid group were significantly decreased（P〈0.05）.The adhesion rate in the hyaluronic acid group was lower than that in the control group（P〈0.05）.Conclusion：Application of hyaluronic acid before abdominal closure during gynecologic surgery can effective prevent adhesions,which may be related to the inflammatory factors inhibition.

关 键 词：妇科 腹腔镜 透明质酸 盆腔黏连 

分 类 号：R713[医药卫生—妇产科学]