辛伐他汀对支气管哮喘合并COPD患者外周血IL-20水平、Th免疫应答和气道重塑的影响  

Effect of Simvastatin on Peripheral Blood IL-20 Level,Th Immune Response and Airway Remodeling in Patients with Bronchial Asthma Complicated with COPD

作　　者：龙明伟 

机构地区：[1]四川省凉山彝族自治州第二人民医院呼吸内科,四川凉山615000

出　　处：《标记免疫分析与临床》2018年第1期113-115,119,共4页Labeled Immunoassays and Clinical Medicine

摘　　要：目的探讨辛伐他汀对支气管哮喘合并COPD患者外周血IL-20水平、Th免疫失衡调节及气道重塑的影响。方法选取我院2010年11月至2017年1月收治的支气管哮喘合并COPD患者1400例,随机分为观察组(n=700)和对照组(n=700)。两组患者皆采用常规治疗,观察组患者加用辛伐他汀片剂,治疗周期为3个月。比较两组肺功能改善情况、血清中白细胞介素20(IL-20)、白细胞介素4(IL-4)以及γ干扰素(INF-γ)水平变化、基底膜厚度(the thickness of bronchial mucosa's reticular basement membrane,TRBM)及黏膜肌纤维母细胞数量变化情况。结果治疗前,两组患者肺功能指标、IL-20、INF-γ及IL-4、TRBM及肌纤维母细胞计数水平对比无差异;治疗后,肺功能均得到明显改善,虽组间对比差异无统计学意义;但观察组IL-20、IL-4、TRBM及肌纤维母细胞计数水平显著下降,且低于对照组,血清INF-γ水平显著上升且高于对照组,组间及组内对比差异均有统计学意义(P<0.05)。结论辛伐他汀对于支气管哮喘合并COPD患者体内炎症反应、免疫机制失衡和气道重塑皆有良好临床疗效,值得广泛采用。Objective To investigate the effect of simvastatin on peripheral blood IL-20 level, Th immune imbalance and airway remodeling in patients with bronchial asthma（ BA） complicated with COPD. Methods 1, 400 patients with BA complicated with COPD treated in our hospital from November 2010 to January 2017 were selected and randomly divided into the observation group（ n = 700）and the control group （n = 700）. Both groups were given conventional treatment, and the observation group were additionally treated with simvastatin tablets for three months. The improvement of pulmonary function, changes of serum levels of intefleukin20 （ IL-20 ）, interleukin 4 （ IL- 4） and interferon γ（ INF-γ）, the thickness of bronchial mucosa＇ s reticular basement membrane （TRBM） and the mucosal myofibroblast count before and after treatment were compared between the two groups. Results Before treatment, there was no difference in lung function indexes, IL- 20, INF-γ, IL-4, TRBM and the mucosal myofibroblast count between the two groups. After treatment, the pulmonary function of the two groups was improved, but there was no significant difference between the two groups. After treatment, levels of IL-20,IL-4 and the mucosal myofibroblast count decreased in the observation group and were lower than those in the control group, wliile INF-γ increased significantly in the observation group and was higher than that in the control group （ all P 〈 0.05 ）. Conclusion Simvastatin is effective in the treatment of BA complicated with COPD in terms of inflammatory reactions,immune imbalance and airway remodeling.

关 键 词：辛伐他汀 支气管哮喘 慢性阻塞性肺疾病 Th免疫应答 气道重塑 炎性反应 

分 类 号：R562.25[医药卫生—呼吸系统] R563.9[医药卫生—内科学]