中-重度变应性鼻炎患者血清25(OH)D水平的相关临床研究  

Clinical study on serum 25(OH)D level in patients with moderate to severe allergic rhinitis

作　　者：檀静怡 刘涛[2] 张丽霞[2] 

机构地区：[1]山西医科大学第一临床医学院,太原030000 [2]山西医科大学第一附属医院耳鼻咽喉头颈外科

出　　处：《临床耳鼻咽喉头颈外科杂志》2018年第3期217-219,共3页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:通过检测中-重度变应性鼻炎(AR)患者血清25(OH)D水平,初步探索维生素D对AR的作用机制,为AR的防治提供佐证。方法:以80例中-重度AR患者及65例健康成人为研究对象,采用酶联免疫吸附试验检测血清25(OH)D水平,并分析中-重度AR患者8种常见血清变应原的血清25(OH)D水平。结果:AR组血清25(OH)D水平为(29.4±4.7)ng/ml,对照组为(30.9±5.9)ng/ml,差异无统计学意义(P>0.05)。AR组血清维生素D缺乏所占百分比为36%,对照组为7%,差异有统计学意义(P<0.05)。在8种常见血清变应原中,对豚草、户尘螨和虾过敏的AR患者,维生素D缺乏和不足所占比例高于对照组,差异有统计学意义(P<0.05)。结论:维生素D缺乏与中-重度AR患者可能存在关联,维生素D对AR的发病进程可能有潜在的有益影响。Objective：Through the detection of the serum 25（OH）D level of patients with moderate to severe allergic rhinitis（AR）,we preliminarily explored the mechanism of vitamin D on AR and provided evidence for the control of AR.Method：Eighty cases of moderate to severe AR and 65 healthy adults were selected as the subjects.The level of 25（OH）D was detected by enzyme-linked immunosorbent assay（ELISA）,and the serum 25（OH）D level of eight common serum allergens in patients with moderate to severe AR was analyzed.Result：The level of serum 25（OH）D of AR group was（29.4±4.7）ng/ml,and the serum level of 25（OH）D in the control group was（30.9±5.9）ng/ml,no significant difference（P〈0.05）.The percentage of serum vitamin D deficiency in AR group was 36%,and the control group was 7%,and the difference was statistically significant（P〈0.05）.Among eight common serum allergens,the AR patients who were allergic to ragweed,household dust mites and shrimps,the percentage of vitamin D deficiency and insufficient was higher than that of the control group,the difference was statistically significant（P〈0.05）.Conclusion：Vitamin D deficiency may be associated with moderate to severe AR patients,and vitamin D may have potential beneficial effects on the progression of AR.

关 键 词：鼻炎 变应性 25(OH)D 变应原 维生素D 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]