冠状动脉严重狭窄患者血浆miRNA-195表达及其与侧支循环形成的关系  

The relationship between the expression of plasma miRNA-195 in patients with severe coronary artery stenosis and its coronary collateral circulation

作　　者：郑颖[1] 李强[1] 阳慧 林德洪 邢波 

机构地区：[1]中南大学湘雅医学院附属海口市人民医院心内科,海口570208

出　　处：《实用医学杂志》2018年第2期265-268,共4页The Journal of Practical Medicine

摘　　要：目的探讨冠状动脉严重狭窄患者血浆mi RNA-195表达及其与侧支循环形成的关系。方法选取2016年3月至2017年5月期间190例接受选择性冠状动脉造影检查的患者作为研究对象,根据Rentrop分级将患者分为侧支循环不良组(90例)与侧支循环良好组(100例),比较两组患者的血浆mi RNA-195和VEGF水平,分析所有入选者血浆mi RNA-195和VEGF水平的相关性以及血浆mi RNA-195和Gensini积分的相关性。结果 (1)侧支循环良好组的血浆mi RNA-195和VEGF水平均明显高于侧支循环不良组,差异具有统计学意义(P<0.05);(2)冠心病患者血浆mi RNA-195与VEGF水平呈正相关性(r=0.628,P=0.022);(3)冠心病患者血浆mi RNA-195与Gensini积分呈正相关性(r=0.765,P=0.013)。结论冠状动脉严重狭窄患者侧支循环的形成过程中,mi RNA-195可能是通过调控VEGF参与了新生血管的生成,可以尝试将其作为预测侧支循环形成的生物标记物供临床参考。Objective To investigate the relationship between the expression of plasma miRNA-195 in pa- tients with severe coronary artery stenosis and its coronary collateral circulation. Methods One hundred and nine- ty patients with selective coronary angiography in our hospital from March 2000 to May 2017 were enrolled, who were divided into poor collateral circulation group （n = 90） and good collateral circulation group （100 cases） ac- cording to the Rentrop classification. Plasma miRNA-195 and VEGF levels were compared between the two groups. The relationship between plasma miRNA-195 and VEGF was analyzed, and also the relationship between plasma miRNA-195 and Gensini points. Results （1） Plasma miRNA-195 and VEGF levels in good collateral circulation group were significantly higher than those in poor collateral circulation group （P 〈 0.05 ）. （2） There was a positive con＇elation between plasma miRNA-195 and VEGF in patients with coronary heart disease （r = 0.628, P = 0.022）. （3） There was a positive correlation between plasma miRNA-195 and Gensini score in patients with coronary heart disease （r = 0.765, P = 0.013）. Conclusion MiRNA-195 may be involved in the production of neovasculariza- tion by regulating VEGF in the formation of collateral circulation in patients with severe coronary artery stenosis, which can be used as a biomarker for predicting the formation of collateral circulation for clinical reference.

关 键 词：冠状动脉严重狭窄 miRNA-195 侧支循环形成 

分 类 号：R543.3[医药卫生—心血管疾病]