奥扎格雷钠注射液联合亚低温治疗颅脑外伤急性脑梗死的临床研究  

Clinical trial of ozagrel sodium injection combined with mild hypothermia in the treatment of craniocerebral injury acute cerebral infarction

作　　者：陈松芳[1] 邹明[1] 何志勇[1] 胡蓓蕾[1] 郭献阳[2] 盛汉松[3] 

机构地区：[1]温州医科大学附属第二医院神经内科,浙江温州325200 [2]温州医科大学附属第二医院重症监护室,浙江温州325200 [3]温州医科大学附属第二医院脑外科,浙江温州325200

出　　处：《中国临床药理学杂志》2018年第3期206-208,共3页The Chinese Journal of Clinical Pharmacology

基　　金：温州市科技计划基金资助项目(Y20100291)

摘　　要：目的观察奥扎格雷钠注射液联合亚低温治疗颅脑外伤急性脑梗死的临床疗效及安全性。方法将62例颅脑外伤急性脑梗死患者随机分为对照组31例和试验组31例。对照组予以静脉注射血栓通注射液每次10 mL,qd;试验组予以静脉滴注奥扎格雷钠注射液每次100 mL,bid联合亚低温治疗。2组患者均治疗14 d。比较2组患者的临床疗效、神经功能缺损评分、Barthel指数、血流动力学指标变化,以及药物不良反应的发生情况。结果治疗后,试验组和对照组的总有效率分别为90.32%(28例/31例)和61.29%(19例/31例),差异有统计学意义(P<0.05)。治疗后,试验组和对照组的神经功能缺损评分分别为(8.24±0.76)和(15.42±1.65)分,Barthel指数分别为(75.23±3.48)和(52.32±3.33)分,全血高切黏度分别为(3.46±0.21)和(4.63±0.26)mPa·s,全血低切黏度分别为(7.69±0.32)和(8.38±0.31)mPa·s,血浆黏度分别为(1.24±0.11)和(1.76±0.16)mPa·s,纤维蛋白原分别为(3.07±0.41)和(4.16±0.18)g·L^(-1),差异均有统计学意义(均P<0.05)。2组患者治疗期间均未发生药物不良反应。结论奥扎格雷钠注射液联合亚低温治疗颅脑外伤急性脑梗死的临床疗效确切,能明显地改善患者的血流动力学指标、神经功能和日常生活活动能力,且安全性较高。Objective To observe the clinical efficacy and safety of ozagrel sodium injection combined with mild hypothermia in the treatment of craniocerebral injury acute cerebral infarction. Methods Sixty-two patients of craniocerebral injury acute cerebral infarction were randomly divided into control group（ n = 31 cases） and treatment group（ n = 31 cases）. Control group was given Xueshuantong injection 10 mL qd,intravenous drip. Treatment group was taken with ozagrel sodium 100 mL bid,intravenous drip,and mild hypothermia treatment. Two groups were treated for 14 d. The clinical efficacy,national institutes of health stroke scale（ NIHSS） scores,Barthel index（ BI）,changes of hemodynamic indexes and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates in treatment and control groups were 90. 32%（ 28 cases/31 cases） and 61. 29%（ 19 cases/31 cases） with significant difference（ P 〈0. 05）. After treatment,the main indexes in treatment and control groups were compared： NIHSSscores were（ 8. 24 ± 0. 76）,（ 15. 42 ± 1. 65） points; BI were（ 75. 23 ± 3. 48）,（ 52. 32 ± 3. 33） points; whole blood high shear viscosity respectively were（ 3. 46 ± 0. 21）,（ 4. 63 ± 0. 26） mPa·s; whole blood low shear viscosity were（ 7. 69 ± 0. 32）,（ 8. 38 ± 0. 31） mPa·s; plasma viscosity were（ 1. 24 ± 0. 11）,（ 1. 76 ± 0. 16） mPa·s; fibrinogen were（ 3. 07 ± 0. 41）,（ 4. 16 ± 0. 18） g·L^（-1）,there were statistically significant differences（ all P〈 0. 05）. No adverse drug reactions were observed during the treatment in two groups. Conclusion Ozagrel sodium injection combined with mild hypothermia has a definitive clinical efficacy and safety in the treatment of craniocerebral injury acute cerebral infarction,which can improve the patient＇s hemodynamic parameters,neurological function and activities of daily living.

关 键 词：奥扎格雷钠注射液 亚低温治疗 颅脑外伤 急性脑梗死 安全性 

分 类 号：R972[医药卫生—药品]