替硝唑片联合盐酸米诺环素软膏治疗慢性牙周炎的临床研究  

Clinical trial of tinidazole tablets combined with minocycline hydrochloride ointment in the treatment of chronic periodontitis

作　　者：张泽标 张莹[1] 黄婉灵[1] 陈燕茹[1] 

机构地区：[1]福建医科大学附属泉州第一医院口腔科,福建泉州362000

出　　处：《中国临床药理学杂志》2018年第3期248-250,共3页The Chinese Journal of Clinical Pharmacology

基　　金：泉州市科技计划基金资助项目(2014Z36)

摘　　要：目的观察替硝唑片联合盐酸米诺环素软膏治疗慢性牙周炎的临床疗效及安全性。方法将94例慢性牙周炎患者随机分为对照组47例和试验组47例。对照组于牙周袋内注满盐酸米诺环素软膏,每周1次;试验组在对照组治疗的基础上,予以替硝唑每次250 mg,qd,口服。2组患者均治疗4周。比较2组患者的临床疗效、龈沟液可溶性细胞间黏附分子1(sICAM-1)、白细胞介素-1β(IL-1β)、单核细胞趋化蛋白-1(MCP-1),以及药物不良反应的发生情况。结果治疗后,试验组和对照组的总有效率分别为95.74%(45例/47例)和80.85%(38例/47例),差异有统计学意义(P<0.05)。治疗后,试验组和对照组龈沟液sICAM-1分别为(87.64±11.20)和(99.87±14.52)μg·L^(-1),IL-1β分别为(25.66±4.21)和(34.81±4.16)μg·L^(-1),MCP-1分别为(28.11±4.65)和(39.36±3.66)ng·L^(-1),差异均有统计学意义(均P<0.05)。2组患者的药物不良反应均以低血压和头痛为主,试验组和对照组的总药物不良反应发生率分别为12.77%和14.89%,差异无统计学意义(P>0.05)。结论替硝唑片联合盐酸米诺环素软膏治疗慢性牙周炎的临床疗效确切,其能降低慢性牙周炎患者龈沟液sICAM-1、IL-1β和MCP-1水平,且不增加药物不良反应的发生率。Objective To observe the clinical efficacy and safety of tinidazole tablets combined with minocycline hydrochloride ointment in the treatment of chronic periodontitis. Methods Ninety-four patients with chronic periodontitis were randomly divided into control and treatment groups with 47 cases per group. Control group was filled with minocycline hydrochloride ointment in the periodontal pocket,once a week. Treatment group was treated with tnidazole 250 mg per time,qd,orally,on the basis of control group. Two groups were treated for 4 weeks. The clinical efficacy,levels of soluble intercellular adhesion molecule 1（ sICAM-1）,interleukin-1β（ IL-1β） in gingivil,monocyte chemoattractant protein-1（ MCP-1） and adverse drug reactions were compared between two groups. Results After treatment,total effective rates of treatment and control groups were 95. 74%（ 45 cases/47 cases） and 80. 85%（ 38 cases/47 cases） with significant difference（ P 〈0. 05）. After treatment,the main indexes in treatment and control groups were compared：sICAM-1 were（ 87. 64 ± 11. 20） and（ 99. 87 ± 14. 52） μg·L^（-1）,IL-1β were（ 25. 66 ± 4. 21） and（ 34. 81 ± 4. 16） μg·L^（-1）,MCP-1 were（ 28. 11 ± 4. 65） and（ 39. 36 ± 3. 66） ng·L^（-1）,the differences were statistically significant（ all P〈0. 05）. The adverse drug reactions of two groups were low blood pressure and headache.The total incidences of adverse drug reactions in treatment and control groups were 12. 77% and 14. 89% without significant difference（ P 〉0. 05）. Conclusion Tinidazole tablets combined with minocycline hydrochloride ointment have a definitive clinical efficacy in the treatment of chronic periodontitis, which can significantly reduce the levels sICAM-1,IL-1β and MCP-1,without increasing the incidence of adverse drug reactions.

关 键 词：替硝唑片 盐酸米诺环素软膏 慢性牙周炎 安全性 

分 类 号：R988.2[医药卫生—药品]