甘精胰岛素注射液联合格列美脲片治疗2型糖尿病的临床研究  

Clinical trial of insulin glargine injection combined with glimepiride tablets in the treatment of type 2 diabetes mellitus

作　　者：张丹丹[1] 孙娜 房辉[1] 张雅中[1] 田金莉[1] 许静[1] 张禾伟[1] 张谷月[1] 甄艳凤[1] 

机构地区：[1]唐山市工人医院内分泌二科,河北唐山063000 [2]华北理工大学生理学教研室,河北唐山063000

出　　处：《中国临床药理学杂志》2018年第3期251-253,共3页The Chinese Journal of Clinical Pharmacology

基　　金：河北省医学科学研究基金资助项目(ZL20140133)

摘　　要：目的观察甘精胰岛素注射液联合格列美脲片治疗2型糖尿病(T2DM)的临床疗效及安全性。方法将45例初治2型糖尿病患者随机分为对照组22例与试验组23例。对照组予以甘精胰岛素,起始剂量为0.2 U·kg^(-1),qd,皮下注射;试验组在对照组治疗的基础上,予以格列美脲每次2~4 mg,qd,口服。2组患者均治疗12周。比较2组患者的血糖达标率和药物不良反应的发生情况。结果治疗后4,8,12周,试验组的血糖达标率分别为91.30%(21例/23例),100.00%(23例/23例)和100.00%(23例/23例),对照组的血糖达标率分别为54.54%(12例/22例),72.72%(16例/22例)和81.81%(18例/22例),差异均有统计学意义(均P<0.05)。试验组发生的药物不良反应以心慌为主,对照组发生的药物不良反应以头晕、心慌、憋气不适和出汗为主。试验组和对照组的总药物不良反应发生率分别为4.35%和31.82%,差异有统计学意义(P<0.05)。结论甘精胰岛素注射液联合格列美脲片治疗初治2型糖尿病的临床疗效确切,可有效地提高血糖达标率,且安全性较高。Objective To observe the clinical efficacy and safety of insulin glargine injection combined with glimepiride tablets in the treatment of type 2 diabetes mellitus（ T2DM）. Methods Forty-five patients with T2DM were randomly divided into control group（ n = 22 cases） and treatment group（ n = 23 cases）. Control group was given insulin glargine with the starting dose of 0. 2 U·kg^（-1）,qd,subcutaneous injection.Treatment group was given glimepiride 2-4 mg,qd,orally,on the basis of the control group. Two groups were treated for 12 weeks. The blood glucose compliance rates and adverse drug reactions were compared between two groups. Results At 4,8,12 weeks after treatment,the blood glucose compliance rates in treatment group were 91. 30%（ 21 cases/23 cases）,100. 00%（ 23 cases/23 cases） and 100. 00%（ 23 cases/23 cases）,which in control group were 54. 54%（ 12 cases/22 cases）,72. 72%（ 16 cases/22 cases） and 81. 81%（ 18 cases/22 cases）,the differences were statistically significant（ all P〈 0. 05）. The adverse drug reactions in treatment group were palpitation,which in control group were dizziness,palpitation,discomfort and sweating. The incidences of adverse drug reactions in treatment and control groups were4. 35% and 31. 82% with significant difference（ P 〈0. 05）. Conclusion Insulin glargine injection combined with glimepiride tablets has a definitive clinical efficacy and safety in the treatment of T2DM,which can significantly improve the blood sugar compliance rate.

关 键 词：甘精胰岛素注射液 格列美脲片 2型糖尿病 安全性 

分 类 号：R977.15[医药卫生—药品]