西地那非致肝内胆汁淤积的病例分析  

Analysis of a case of sildenafil-induced intrahepatic cholestasis

作　　者：李璐[1] 梁京津[1] 裴斐[2,3] 胥婕[1] 

机构地区：[1]北京大学第三医院感染疾病科,北京100191 [2]北京大学第三医院病理科,北京100191 [3]北京大学医学部病理学系,北京100191

出　　处：《中国临床药理学杂志》2018年第3期350-352,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的探讨西地那非导致肝损伤的临床表现及处理措施。方法通过对1例男性患者应用西地那非致肝内胆汁淤积的案例报道,并结合相关文献报道进行分析。结果和结论西地那非引起的肝损害少见,但仍需警惕。肝损伤的类型可表现为转氨酶升高,或重度胆汁淤积。使用西地那非时应定期监测肝功能。Objective To discuss the clinical manifestations and treatment of sildenafil-induced liver injury. Methods A case report of intrahepatic cholestasis induced by sildenafil in 1 male patients as well as related case reports in literatures were analyzed. Results and conclusion The few cases reported to date suggest that sildenafil-associated liver damage is rare but it still needs to be carefully watched out. The pattern of liver injury can be manifested as elevated transaminase or severe cholestasis. Regular monitoring liver function should be performed when using sildenafil.

关 键 词：西地那非 药物性肝损伤 胆汁淤积 

分 类 号：R977[医药卫生—药品]