甘氨双唑钠对食管癌放疗增敏作用疗效与安全性的分析  

Analysis of effectiveness and safety of sodium glycididazole on radiotherapy for esophagus cancer

作　　者：杨珍珍 王凯[1] 韩晟[2] 张志清[1] 

机构地区：[1]河北医科大学第二医院药学部,石家庄050000 [2]北京大学医学部药学院,北京100191

出　　处：《中国临床药理学杂志》2018年第3期365-368,共4页The Chinese Journal of Clinical Pharmacology

基　　金：安徽省卫生厅科研计划基金资助项目(13FR021)

摘　　要：目的系统性评价甘氨双唑钠(CMNa)对食管癌同步放疗增敏作用的临床疗效和安全性。方法检索中国期刊全文数据库、万方医药期刊全文数据库、维普中文科技期刊数据库,MedLine(PubMed)数据库,截至2017年5月,收集放疗联合CMNa治疗食管癌(试验组)和单独放疗治疗食管癌(对照组)的临床随机对照试验。用Rev Man 5.3软件对入选文献的完全缓解率、有效率、生存率和药物不良反应进行Meta分析。结果共纳入13篇相关文献,共计1073名患者。试验组和对照组的有效率分别为92.71%(496例/535例)和77.32%(416例/538例),完全缓解率分别为43.55%(233例/535例)和25.28%(136例/538例),1年生存率分别为78.92%(131例/166例)和53.76%(93例/173例),差异均有统计学意义(P<0.001,P<0.01)。2组患者治疗期间均未出现严重药物不良反应,试验组和对照组的总药物不良反应发生率分别为41.94%(78例/186例)和43.00%(83例/193例),差异无统计学意义(P>0.05)。结论 CMNa对食管癌放疗增敏作用的近期疗效确切,安全性良好,但远期疗效有待进一步临床试验研究。Objective To systematically evaluate the effectiveness and safety of sodium glycididazole（ CMNa） combined with radiotherapy in the treatment of esophagus cancer. Methods Databases including China National Knowledge Infrastructure,Wanfang Database,VIP and MedLine（ PubMed） database were searched,and the date of publication was up to May 2017. Randomized controlled trials of CMNa combined with radiotherapy（ treatment group） and radiotherapy alone（ control group） in the treatment of esophagus cancer were retrieved from these datebases. Complete response rate、effective rate、survival rate and adverse drug reactions were performed by using Rev Man 5. 3 statistical software. Results A total of 13 articles were included,involving 1073 patients. Effective rates of treatment and control groups were 92. 71%（ 496 cases/535 cases） and77. 32%（ 416 cases/538 cases）,complete response rates of treatment and control groups were 43. 55%（ 233 cases/535 cases） and 25. 28%（ 136 cases/538 cases）,one year survival rate of treatment and control groups were 78. 92%（ 131 case/166 case） and 53. 76%（ 93 case/173 case）,all discrepancies had statistical differences（ P〈 0. 001,P〈 0. 01）.There were no serious adverse drug reactions in both groups. Total incidences of adverse drug reactions in treatment and control groups were 41. 94%（ 78 cases/186 cases） and 43. 00%（ 83 cases/193 cases） without statistically difference（ P 〉0. 05）. Conclusion CMNa on radiotherapy for esophagus cancer is reliable in the short term,with a good safety. But the long-term effects need to be further studied in clinical trials.

关 键 词：食管癌 甘氨双唑钠 放疗 META分析 

分 类 号：R973[医药卫生—药品]