药物利用评价法联合药物利用评估法评价慢性阻塞性肺疾病患者的用药情况  

Evaluation of the drugs utilization of chronic obstructive pulmonary disease patients by drug evaluation review and drug utilization evaluation

作　　者：周家军[1] 陈芳[1] 姜怡[1] 孟祥云[1] 邢海燕[1] 刘建军[1] 

机构地区：[1]合肥市第二人民医院药学部,合肥230030

出　　处：《中国临床药理学杂志》2018年第3期369-370,386,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的评价我院慢性阻塞性肺疾病住院患者的用药合理性。方法药物利用评价法(DUR)联合药物利用评估法(DUE)评价我院27例慢性阻塞性肺疾病住院患者的用药情况。结果 27例患者所用主要治疗药物共37种,其中13种药物利用指数>1,13种药物利用指数<1,11种药物利用指数=1。用药强度(DDDs)居前列的药物为注射用头孢地嗪、注射用美罗培南、氨溴索注射液、泮托拉唑粉针、雷贝拉唑肠溶片、呋噻米片和螺内酯片。治疗期间患者进行了血常规(77.78%和84.62%)、肝功能(100.00%和62.50%)、肾功能(92.59%和72.73%)和心功能(81.84%和75.00%)的监测和异常再监测。经过治疗后,24例(88.89%)患者临床症状明显好转,22例(81.84%)患者并发症得到控制。结论 DUR联合DUE可更好地评价慢性阻塞性肺疾病患者的用药情况,及时发现用药不合理的现象,促进医院药品的合理使用。Objective To evaluate the rationality of the drug utilization in patients with chronic obstructive pulmonary disease（ COPD） in our hospital. Methods The methods of drug utilization review（ DUR） and drug utilization evaluation（ DUE） were used to analyze the drug utilization of 27 patients with COPD in our hospital. Results There were 37 main therapeutic drugs in 27 patients,and drug utilization index（ DUI）of 13 cases were more than 1,DUI of 13 cases were less than 1,while DUI of 11 cases were equal to 1. The top DDDs of drugs（ DDDs） in terms were cefodizime injection,meropenem for injection,ambroxol injection,pantoprazole injection,rabeprazole sodium enteric-coated tablets,furosemide tablets and spironolactone tablets. During the therapeutic process,routine blood tests（ 77. 78% and 84. 62%）,liver function（ 100. 00% and 62. 50%）,renal function（ 92. 59% and 72. 73%） and cardiac function（ 81. 84% and 75%） were monitored and abnormal remonitoring was performed. 24 cases（ 88. 89%） of the patients showed obvious improvement and 22 cases（ 81. 84%） complications were controlled after treatment. Conclusion A more comprehensive evaluation of drug utilization in patients with COPD can be achieved by using DUR plus DUE method,helping to find out the irrational drug use and promote the rational use of medicines in hospital.

关 键 词：慢性阻塞性肺疾病 药物利用评价 药物利用评估 药物利用指数 

分 类 号：R97[医药卫生—药品]