β3肾上腺素受体与心血管疾病相关性的研究进展  

Research progress of the relationship between β3-adrenoceptor and cardiovascular diseases

作　　者：张梓桑 张薪茹 李光宇[1] 张劲松[1] 杜荣增[1] 

机构地区：[1]江苏大学附属医院心内科,江苏省镇江市212001 [2]溧阳市人民医院心内科,江苏省溧阳市213300

出　　处：《中国动脉硬化杂志》2018年第2期207-212,共6页Chinese Journal of Arteriosclerosis

基　　金：镇江市社会发展基金项目(SH2015036)

摘　　要：心血管疾病如心肌梗死、慢性心力衰竭等是人类死亡的主要原因。现已明确脂代谢功能障碍、糖尿病等是心血管疾病发生和发展的重要危险因素。心肌结构的变化、Ca^（2＋）信号传导、细胞代谢、氧化应激、肾素-血管紧张素系统的激活和线粒体功能障碍都与心血管疾病的发生发展有关。自1989年发现β_3肾上腺素受体（β_3-AR）以来,研究者又陆续发现β_3-AR与心血管疾病存在相关性,并且激动β_3-AR可以调节脂代谢,改善心脏功能及重塑,预防和治疗心血管疾病。Cardiovascular diseases, such as myocardial infarction, chronic heart failure, are the main causes of human death. It is clear that lipid metabolic dysfunction, diabetes and so on are important risk factors for the occurrence and development of cardiovascular diseases. Changes in myocardial structure, Ca2＋ signaling, cellular metabolism, oxidative stress, activation of renin-angiotensin system and mitochondrial dysfunction are associated with the development of cardio- vascular diseases. Since β3-adrenoceptor （ β3-AR） has been cloned in 1989, the researchers have found that 133-AR is associated with cardiovascular diseases. β3-AR stimulation can regulate lipid metabolism, improve cardiac function and remodeling, therefore, perhaps prevent and treat cardiovascular diseases.

关 键 词：Β3肾上腺素受体 心血管疾病 动脉粥样硬化 

分 类 号：R5[医药卫生—内科学]