基于介电泳原理的三明治式微流控芯片  

Sandwiched Microfluidic Chip Based on the Principle of Dielectrophoresis

作　　者：吴菲[1,2] 樊磊[1,2] 曾一笑 谭秋林[1,2] 孙东[1,2] 

机构地区：[1]中北大学电子测试技术重点实验室,太原030051 [2]中北大学仪器科学与动态测试教育部重点实验室,太原030051

出　　处：《微纳电子技术》2018年第2期116-121,共6页Micronanoelectronic Technology

基　　金：山西省基础研究项目(2014011021-3)

摘　　要：根据介电泳的工作原理,利用粒子介电性质的不同设计了基于双层微电极结构的芯片模型,实现了介电性质不同的粒子的断续分离。采用COMSOL软件仿真并分析了芯片内部的电场强度和介电泳力的分布;对比二维微流控芯片和三明治式微流控芯片,发现三明治式微流控芯片可以克服电场强度在通道高度方向上的衰减。用三明治式微流控芯片进行粒子的断续分离,与二维微流控芯片进行实验对比,结果显示,在酵母菌细胞与聚苯乙烯小球的断续分离实验中,三明治式微流控芯片的分离效率为95.2%,比二维微流控芯片的分离效果好、分离效率高。According to the working principle of electrophoresis,a chip model with a double-deck microelectrode structure was designed by using different particle dielectric properties,and the intermittent separation of the particles with different dielectric properties was realized.The distributions of the electric field intensity and electrophoresis force inside the chip were simulated and analyzed by the COMSOL software.Through the comparison of the 2D microfluidic chip and sandwiched microfluidic chip,it is found that the sandwiched microfluidic chip can overcome the attenuation of the electric field intensity in the direction of the channel height.The sandwiched microfluidic chip was used for the intermittent separation of the particles.Compared with the experiment of the 2D microfluidic chip,the experimental results show that the separation efficiency of the sandwiched microfluidic chip are 95.2%,and the separation effect and separation efficiency of the sandwiched microfluidic chip are better than those of the 2D microfluidic chip in the intermittent separation experiment of yeast cells and polystyrene pellets.

关 键 词：介电泳 三明治式微流控芯片 细胞分离 COMSOL软件 介电性质 

分 类 号：O35[理学—流体力学] TH703[理学—力学]