原发性干燥综合征的自身抗体研究进展  

Advances in research on autoantibodies of primary sjgren's syndrome

作　　者：喻晓雯[1] 王琴[1] 冯婧 白殊同[1] 刘金坤[1] 高洪燕[1] 吴斌[1] YU Xiao-Wen;WANG Qin;FENG Jing;BAI Shu-Tong;LIU Jin-Kun;GAO Hong-Yan;WU Bin(Basic ResearchLaboratory,Chongqing Hospital of Traditional Chinese Medicine,Chongqing 400021,China)

机构地区：[1]重庆市中医院中医药基础研究室,重庆400021

出　　处：《中国免疫学杂志》2018年第2期301-305,共5页Chinese Journal of Immunology

基　　金：重庆市科委项目(cstc2016shms-zd10001;cstc2015jcyj B0383);重庆市中医院院内课题(2016-1-5;2016-1-6)

摘　　要：原发性干燥综合征是一种累及外分泌腺的慢性自身免疫性疾病。研究发现原发性干燥综合征与多种自身抗体相关,如抗Ro/SSA抗体、抗La/SSB抗体、抗M3R抗体、抗α-胞衬蛋白抗体、抗ADAMTS13抗体、抗NA-14抗体、抗IFN-γ抗体、抗REGⅠα抗体、抗MDM2抗体等。本文对近年来自身抗体在原发性干燥综合征的疾病预测、诊断、发病机制等的进展进行了综述,以期为原发性干燥综合征的临床及科研提供新的思路。Primary Sjogren＇s syndrome（ p SS） is a chronic autoimmune disease which is characterized by exocrine gland damage. Studies have found that p SS is associated with a variety of autoantibodies,including anti-Ro/SSA,-La/SSB,-M3 R,-α-fodrin,-ADAMTS13,-NA-14,-IFN-γ,-REG Iα,-MDM2. In this paper,we reviewed the progress of autoantibodies in the diagnosis,disease prediction and pathogenesis of p SS in recent years,so as to provide new ideas for p SS clinical and scientific research.

关 键 词：原发性干燥综合征 自身抗体 诊断 发病机制 

分 类 号：R392[医药卫生—免疫学]