叶酸干预对急性冠脉综合征患者PCI术后Hcy、FIB浓度及预后的影响  

Effect of folic acid intervention on the concentration and prognosis of Hcy,FIB in patients with acute coronary syndrome after PCI

作　　者：齐囡囡 刘松[1] Qi Nannan;Liu Song(Corresponding author）Department of Cardiology,Affiliated Hospital of Qiingdao University Medical School 26600)

机构地区：[1]青岛大学医学院附属医院心内科,266003

出　　处：《中国社区医师》2018年第5期54-55,57,共3页Chinese Community Doctors

摘　　要：目的:探讨叶酸对急性冠脉综合征(ACS)患者PCI术后同型半胱氨酸(Hcy)、纤维蛋白原(FIB)的浓度及短期预后的影响。方法:将ACS患者分为不稳定型心绞痛组(UAP)组(A组)、非ST抬高型心肌梗死(NSTEMI)组(B组)、ST抬高型心肌梗死(STEMI)组(C组),3组再随机分对照组和治疗组。治疗组在常规治疗基础上加服叶酸,观察PCI术后4周、12周、24周治疗组与对照组的Hcy、FIB的浓度及MACE事件发生情况。结果:叶酸干预治疗后治疗组和对照组的Hcy、FIB浓度、MACE的发生差异有统计学意义(P<0.05)。结论:叶酸干预可以降低ACS患者PCI术后Hcy、FIB的浓度,减少MACE事件的发生。Objective：To investigate the effect of folic acid on the concentration of homocysteine（Hcy）,fibrinogen（FIB）and short-term prognosis in patients with acute coronary syndrome（ACS）after PCI.Methods：ACS patients were divided into the unstable angina group（UAP）group（the group A）,the non ST segment elevation myocardial infarction（NSTEMI）group（the group B）,the ST segment elevation myocardial infarction（STEMI）group（the group C）.The 3 groups were randomly divided into the control group and the treatment group.The treatment group was supplied with folic acid on the basis of routine treatment.The concentration of Hcy and FIB and the occurrence of MACE events in the treatment group and the control group at 4,12 and 24 weeks after PCI were observed.Results：There was significant difference in the difference of Hcy,FIB concentration and MACE between the treatment group and the control group after received the treatment of folic acid（P0.05）.Conclusion：Folic acid intervention can reduce the concentration of Hcy and FIB in patients with ACS after PCI,and reduce the occurrence of MACE events.

关 键 词：叶酸 急性冠脉综合征 同型半胱氨酸 纤维蛋白原 

分 类 号：R541.4[医药卫生—心血管疾病]