缓解期双相障碍Ⅰ型患者脑半球间静息态功能连接的探讨  

Interhemispheric resting state functional connectivity in bipolar Ⅰ euthymia

作　　者：成小芳 邓文皓[2] 陈建山 张一智 邹文锦[1] 崔立谦[4] 黄癸卯[1] 曹莉萍[2] CHENG Xiao-fang;DENG Wen-hao;CHEN Jian-shan;ZHANG Yi-zhi;ZOU Wen-jin;CUI Li-qian;HUANG Gui-mao;CAO Li-ping(Department of Radiology, Affliated Brain Hospital of Guangzhou Medical University （Guangzhou Huiai Hosiptal）, Guangzhou 510370, China;Department of Early Intervention, Affliated Brain Hospital of Guangzhou Medical University （Guangzhou Huiai Hosiptal）, Guangzhou 510370, China;Department of Neurology, General Hospital of Guangzhou Military Command of PLA, Guangzhou 510010, China;Department of Psychology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China)

机构地区：[1]广州医科大学附属脑科医院(广州市惠爱医院广州市脑科医院)放射科,广州510370 [2]广州医科大学附属脑科医院(广州市惠爱医院广州市脑科医院)早期干预科,广州510370 [3]广州军区广州总医院神经内科,广州510010 [4]中山大学附属第一医院心理科,广州510080

出　　处：《磁共振成像》2018年第1期3-8,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金重大研究计划项目(编号:91332205);广东省科技计划项目(编号:2013B021800074)~~

摘　　要：目的神经影像学研究提示双相障碍(bipolar disorder,BD)患者脑结构及功能连接异常,而BD相关大脑半球间功能交互作用变化仍不清,静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-f MRI)方法反映f MRI信号内神经元自发活动特征,为定量研究双侧大脑半球交互作用提供了有利的手段。本研究采用有效的评价方法,即基于体素镜像同伦功能连接,探讨缓解期BDⅠ型患者双侧大脑半球同步活动模式及其与临床特征的相关性。材料与方法对27例缓解期BDⅠ型患者及27例健康匹配对照进行磁共振扫描,将rs-f MRI数据配准到高清T1对称解剖模板后,计算两侧半球镜像同伦体素间同伦功能连接,进行进一步的统计分析。结果岛盖部额下回、罗兰迪克岛盖、岛叶、壳核功能同伦连接减低(P<0.05,高斯随机场校正,团块校正);岛盖部额下回及罗兰迪克岛盖同伦功能连接值与病程呈负相关(r=-0.402,P=0.037;r=-0.402,P=0.038)。结论缓解期BDⅠ型患者多个半球间镜像脑区存在功能协同性的损害,特别是岛盖部额下回及罗兰迪克岛盖脑区可能在疾病慢性化过程中起重要作用。Objective： Abnormalities in structural and functional brain connectivity have been increasingly reported in patients with bipolar disorder （BD） by recent neuroimaging studies. However, BD-related alterations in interhemispheric functional interaction are still largely unclear. Resting-state functional magnetic resonance imaging （rs-fMRI） approaches, which reveal patterns of coherent spontaneous fuctuations in the fMRI signal, provide a means to quantitatively detect interhemispheric functional interaction pattern. We examined interhemispheric resting-state functional connectivity （RSFC） and its relationships with clinical characteristics in bipolarⅠeuthymia using a recently validated approach, voxel-mirrored homotopic connectivity （VMHC）. Materials and Methods： Euthymic subjects with bipolar I disorder （n=27） and matched healthy subjects （n=27） underwent resting-state functional magnetic resonance imaging scans. rs-fMRI data were co-registered to the high-resolution T1 symmetric anatomical template, and the homotopic resting state functional connectivity was computed for each subject. Results： Group comparisons revealed that patients exhibited lower VMHC than healthy subjects in inferior frontal gyrus （opercular part）, Rolandic operculum, insula, putamen （P〈0.05, GRF corrected）. Negative correlation was found between the duration of BD and VMHC in the inferior frontal gyrus and Rolandic operculum （r=-0.402, P=0.037; r=-0.402, P=0.038）. Conclusions： These findings suggest substantial impairment of functional coordination between homotopic brain regions in bipolarⅠeuthymia. Inferior frontal gyrus and rolandic operculum may have a role in the chronicity of BD.

关 键 词：双相障碍 缓解期 静息态 半球间 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R742[医药卫生—诊断学]