硫酸特布他林肺部吸入给药对支气管哮喘患儿的影响  

Effects of Pulmonary Inhalation of Terbutaline Sulfate on Children With Bronchial Asthma

作　　者：李勇 LI Yong(The Fourth Internal Medicine Department, Jingzhou Infectious Disease （Chest） Hospital, Jingzhou Hubei 434020, Chin)

机构地区：[1]荆州市传染病(胸科)医院内四科,湖北荆州434020

出　　处：《中国继续医学教育》2018年第4期104-106,共3页China Continuing Medical Education

摘　　要：目的研究硫酸特布他林肺部吸入给药对支气管哮喘患儿血浆外周血嗜酸性粒细胞计数及β_2-肾上腺素能受体的影响。方法选取68例患儿分成观察组和对照组,各34例,对照组采用多索茶碱常规治疗,观察组加用硫酸特布他林,观察两组治疗前后的血浆外周血嗜酸性粒细胞计数和β2_-肾上腺素能受体的变化情况。结果对照组治疗前后的血浆外周血中β_2-肾上腺素能受体均无明显变化,差异无统计学意义(P>0.05),观察组治疗后β_2-肾上腺素能受体降低(P<0.05);治疗后,血浆外周血嗜酸性粒细胞计数均有明显的减少,观察组较对照组减少更为明显(P<0.05)。结论硫酸特布他林肺部吸入给药会降低支气管哮喘患儿血浆外周β_2-肾上腺素能受体水平,可减少患儿血浆外周血嗜酸性粒细胞计数。Objective To study the effect of inhaled terbutaline sulfate on plasma eosinophil counts and β2-adrenergic receptor in children with bronchial asthma. Methods A total of 68 cases of patients were divided into observation group and control group, each of 34 cases, the control group using conventional doxofylline treatment, observation group were treated with terbutaline sulfate, the changes of eosinophil count and β2- adrenergic receptor in plasma peripheral blood before and after treatment were observed before and after treatment in two groups. Results There was no signifcant change in the β2- adrenergic receptor in the plasma peripheral blood before and after treatment in the control group, and the difference was not statistically signifcant （P 〉 0.05）. The β2- adrenergic receptor decreased after treatment in the observation group （P 〈 0.05）. After treatment, the eosinophil count of plasma peripheral blood decreased signifcantly, and the decrease of the observation group was more obvious than that of the control group （P 〈 0.05）. Conclusion The inhalation of terbutaline sulfate can reduce the plasma level of peripheral β2- adrenergic receptor in asthmatic children, and decrease the plasma eosinophil count in plasma.

关 键 词：支气管哮喘 硫酸特布他林 Β2-肾上腺素能受体 嗜酸性粒细胞 

分 类 号：R562[医药卫生—呼吸系统]