多排CT测量健康者左心房容积参考值  

Measurement of left atrial volume reference value in healthy subjects by Multi-slice Computed Tomography

作　　者：郭平 陈光志 白杨[1] 王炎[1] GUO Ping;CHEN Guangzhi;BAI Yang;WANG Yan(Department of Cardiology,Tongji Hospital,Affiliated to Tongji Medical College of Huazhong University of Science and Technolog)

机构地区：[1]华中科技大学同济医学院附属同济医院心血管内科,武汉430030

出　　处：《检验医学与临床》2018年第4期444-446,450,共4页Laboratory Medicine and Clinic

基　　金：国家自然科学基金面上项目(81570308)

摘　　要：目的初步制订健康者左心房容积的CT参考值范围,并评估心血管危险因素对左心房容积大小的影响。方法选择2014年2月至2015年6月该院行冠状动脉成像检查的无心血管疾病的健康者107例(男61例,女46例),平均年龄(57.27±10.53)岁。将107例患者分别按性别及有无吸烟、饮酒分组,对各组及亚组应用多排CT三维重建和半自动后处理技术测量左心房容积的最大值。相关性分析心血管疾病的危险因素,性别、年龄、吸烟、饮酒、体表面积对左心房容积的影响。结果总体平均左心房容积最大值为87.45cm^3(正常参考值范围为70.40~104.50cm^3),男性最大左心房容积平均值为89.67cm^3(正常参考值范围为72.81~105.86cm^3),女性最大左心房容积平均值为84.50cm^3(正常参考值范围为68.82~100.18cm^3),男性组平均最大左心房容积大于女性组,差异有统计学意义(P=0.002,<0.05)。吸烟组平均最大左心房容积大于非吸烟组,差异有统计学意义(P<0.05),饮酒组与非饮酒组比较,差异无统计学意义(P=0.856,>0.05)。多元线性回归分析显示,年龄、体表面积与左心房容积呈正相关。结论多排CT的三维重建半自动容积测量法评估左心房容积是一种简便、可行且重复性好的测量方法,初步制订了健康者左心房容积最大值的参考值标准,为临床评估左心房增大提供了依据,证实了心血管危险因素与左心房大小的相关性。Objective To quantitatively establish the normal reference value ranges of the left atrial volume（LAV）and evaluate the influences of the cardiovascular risk factors on the LAV by multi-slice computed tomography（MSCT）on individuals free of cardiovascular disease.Methods From February 2014 to June2015,the ＂ normal＂ Chinese individuals（excluding cardiovascular disease）in sinus rhythm who underwent electrocardiogram（ECG）-gated coronary CT angiography（CTA）at our institution were enrolled in the study.All the individuals had their LAVmax,at end ventricular systole（just prior to mitral valve opening）,calculated by the MSCT semi-automatic segmentation method.The influences of the cardiovascular risk factors [age,gender,body surface area（BSA）,smoking,drinking]on the LAV were assessed.Results The study was conducted on 107（male 61 cases,female 46 cases）subjects mean age（57.27±10.53）years,the mean of the normal reference value of the MSCT LAVmax was 87.45 cm^3（the normal reference value ranges of the LAVmax was 70.40 cm^3 to 104.50 cm^3）,and 89.67 cm^3 for the male（72.81 cm^3 to 105.86 cm^3）,and 84.50 cm^3 for the female（68.82 cm^3 to 100.18 cm^3）.The LAVmax in the male group was higher than those in the female group,the difference was statistically significant（P〈0.05）.The LAVmax in the smoking group was higher than those in the nonsmoking group,the difference was statistically significant（P〈0.05）.The LAV max in the drinking group has no difference with those in the nondrinking group（P=0.856,〉0.05）.In the study,LAV max was increased with advancing age,BSA and smoking,and no significant difference was found with drinking.Conclusion The study demonstrated a feasible and repeatable method to measure the LAV by MSCT,and established the MSCT normal reference value ranges of the LAVmax in a healthy group,which provided a standard for the diagnosis of the LA enlargement.In addition,we came to a conclusion that people with the association of the cardiovascular r

关 键 词：左心房容积 多排CT 半自动测量法 

分 类 号：R540.4[医药卫生—心血管疾病]