胸腺粘液腺癌的临床病理特征分析  

Clinicopachologic analysis of primary thymic mucinous adenocarcinoma

作　　者：程显魁[1] 林万润[1] 苏贞辉[1] 范慧[1] 李亚琼 吴大号[2] 侯东省 

机构地区：[1]山东大学附属省立医院病理科,山东济南250021 [2]山东大学附属省立医院神经外科,山东济南250021

出　　处：《西南医科大学学报》2018年第1期49-53,共5页Journal of Southwest Medical University

基　　金：国家自然科学基金青年基金(81300647)

摘　　要：目的:探讨原发性胸腺粘液腺癌的临床病理特征。方法:分析1例原发性胸腺粘液腺癌患者的临床实验室检查及影像学检查结果,并对相关文献进行复习。结果:本例肿瘤位于前纵膈胸腺位置,边界较清,肿瘤呈实性,局部见囊腔;临床实验室检查及影像学检查均能除外其他部位肿瘤转移。镜下组织形态为:乳头状、腺泡样、以及筛状结构,肿瘤细胞漂浮于大量粘液样的背景中。免疫组化阳性的指标有CK20、CD117、CDX2、Cam5.2、CK、CK19、MUC2和CEA;阴性的指标有:TTF-1、Synaptophysin、Chromogranin A、CR、CK7、MC、TdT、Vim、p63、S-100、CK5/6、CD1a以及CD5。结论:本例腺癌从大体特征、组织形态、以及免疫特性上,均支持是源发于胸腺的粘液腺癌。Objective: Discuss the clinicopathological characteristics of a primary thymic mucinous adenocarcinoma. Methods:Analysis the clinical laboratory test and radiographic examination of this case, and review the related papers. Results: This solid tumor was located in the anterior mediastinum with cleaner margins, local cavity was existed. With clinical and radiographic examinations disclosed no evidence of tumor elsehere. Histologically, the tumors were classified as a mucinous adenocarcinoma; it demonstrated papillary, acinar, and cribriform structure, and produced abundant extracellular mucin. Immunohistochemically, the tumors was positive for CK20, CD117, CDX2,Cam5.2, CK, CK19, MUC2 and CEA, and were negative for TTF-1, synaptophysin, Chromogranin A, CR, CK7, MC,TdT, Vim, p63,S-100,CK5/6,CD1 a, and CD5. Conclusions: According to the gross image, histological morphology,and immunohistochemical result, this case could be diagnosed as primary thymic mucinous adenocarcinoma.

关 键 词：胸腺 粘液腺癌 前纵膈 

分 类 号：R602[医药卫生—外科学]