保肺解窘合剂治疗脓毒症致轻度急性呼吸窘迫综合征疗效观察  

Clinical observation of BaoFei JieJiong Mixture in the treatment of mild acute respiratory distress syndrome induced by sepsis

作　　者：苏玉杰[1] 胡瑞[1] 李云华[1] 胡浩英[2] 刘晓敏[2] 宋欠红[1] 

机构地区：[1]云南中医学院,云南昆明650011 [2]云南省中医医院,云南昆明650021

出　　处：《现代中西医结合杂志》2018年第7期685-688,715,共5页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：国家中医药管理局课题(zyLc20150633)

摘　　要：目的观察保肺解窘合剂辅助治疗脓毒症致轻度急性呼吸窘迫综合征患者的有效性和安全性。方法将60例脓毒症致轻度急性呼吸窘迫综合征患者随机分为2组,对照组30例采用西医规范化治疗,治疗组30例在西医治疗基础上给予保肺解窘合剂治疗,疗程7 d。监测2组治疗前、治疗第3天、治疗第7天氧合指数和急性生理和慢性健康评分(APACHEⅡ评分),记录治疗过程中有创机械通气情况、不良反应发生情况和中重度急性呼吸窘迫综合征和多脏器功能衰竭综合征发生情况,统计2组治疗7 d后西医综合疗效、中医症状疗效。结果治疗第3天,2组氧合指数均明显高于治疗前(P均<0.05),且治疗第7天明显高于第3天(P均<0.05),治疗组明显高于同期对照组(P均<0.05);2组APACHEⅡ评分明显低于治疗前(P均<0.05),且治疗第7天明显低于第3天(P均<0.05),治疗组明显低于同期对照组(P均<0.05)。治疗组有创机械通气率及中重度急性呼吸窘迫综合征和多脏器功能衰竭综合征发生率均明显低于对照组(P均<0.05),中医症状疗效总有效率明显高于对照组(P<0.05),2组不良反应均轻微。结论保肺解窘合剂辅助治疗脓毒症致轻度急性呼吸窘迫综合征疗效优于单纯西医治疗,可有效改善氧合指数,减少有创机械通气的使用和中重度急性呼吸窘迫综合征及多脏器功能衰竭综合征的发生。Objective It is to observe the clinical efficiency and safety of Bao Fei Jie Jiong Mixture in the treatment of mild acute respiratory distress syndrome induced by sepsis. Methods Sixty patients with mild acute respiratory distress syndrome caused by sepsis were randomly divided into treatment group( 30 cases) and control group( 30 cases),the control group was treated with standardized therapy of western medicine,and the treatment group was treated with Bao Fei Jie Jiong Mixture on the basis of treatment in the control group. Both groups were treated for 7 days. The oxygenation index,acute physiology and chronic health evaluation Ⅱ( APACHE Ⅱ) before treatment and after treatment for 3 days,7 days were detected,invasive mechanical ventilation and occurrence of side effects,moderate and severe acute respiratory distress syndrome and multiple organ dysfunction syndrome during treatment were recorded in both groups. The comprehensive curative effect of western medicine and curative effect of Chinese Medicine between the two groups were compared. Results After treatment for 3 days,the oxygenation indexes were higher while the APACHE Ⅱ scores were lower than those before treatment in both groups( P < 0. 05),the oxygenation indexes were the highest while APACHE Ⅱ scores were the lowest after treatment for 7 days in both groups( P < 0. 05). Furthermore,the improvements of these indexes at the same time were better in the treatment group than those in the control group( P < 0. 05). The rate of invasive mechanical ventilation and occurrence rate of moderate and severe acute respiratory distress syndrome and multiple organ dysfunction syndrome in the treatment group were significantly lower than those in the control group( P < 0. 05). The total effective rate of curative effect of Chinese Medical symptoms in the treatment group was higher than that in the control group( P < 0. 05). No severe side effect was found during treatment in both groups. Conclusion The assistant treatment with Bao Fei Jie Jiong Mixture could

关 键 词：脓毒症 急性呼吸窘迫综合征 保肺解窘合剂 

分 类 号：R631[医药卫生—外科学]