糖尿病肥胖患者减重治疗对性腺功能的影响  

Effectiveness of weight loss treatment on gonadal function in diabetic patients with obesity

作　　者：崔佳[1] 陈微 窦京涛[1] 

机构地区：[1]中国人民解放军总医院内分泌科,北京100853 [2]内蒙古兴安盟人民医院内分泌科,乌兰浩特137400

出　　处：《药品评价》2018年第3期54-59,共6页Drug Evaluation

摘　　要：糖尿病通过影响下丘脑-垂体-性腺轴导致性腺功能减退;肥胖亦可诱发性腺功能减退,同时作为糖尿病的独立危险因素,可加重糖尿病患者的胰岛素抵抗和慢性炎症,进一步加重性腺功能障碍。因此,需要有效的治疗手段来改善糖尿病患者的肥胖状态。本文将在阐述糖尿病与肥胖相互关系和二者对下丘脑-垂体-性腺轴影响的基础上,着重探讨现有糖尿病肥胖患者减重治疗对性腺功能的影响。Poorly managed diabetes can lead to hypogonadism. This effect might be mediated through hormonal alterations in the hypothalamic pituitary gonadal axis. Gonadal dysfunction also occur in obese patients. Obesity is a crucial public health concern given its contribution to the risk of diabetes. The growing evidence supports the existence of significant interactions between diabetes and obesity, with chronic infiammation and insulin resistance increase, and consequently excessive fat accumulation, all these factors contributing to the development of gonadal dysfunction. Maintaining body homeostasis is a prerequisite for normal reproductive function, which is vital for the survival of the species and an important process of natural selection. This article will characterize the relationship between diabetes and obesity, and the effect of the disease on the hypothalamus-pituitary-gonadal axis. We will focuse on the impact of weight loss treatment on gonadal functionin diabetic patients with obesity.

关 键 词：肥胖合并2型糖尿病 减重治疗 性腺功能 

分 类 号：R587.1[医药卫生—内分泌]