长链非编码RNA的功能与疾病治疗的潜力  

Function of Long Non-Coding RNA and Its Potentials for Clinical Therapy

作　　者：隗思媛 孟畅 李淑艳[1] 

机构地区：[1]北京大学基础医学院生物化学与分子生物学系,北京市蛋白质翻译后修饰和细胞功能重点实验室,北京100191

出　　处：《中国生物化学与分子生物学报》2018年第2期129-136,共8页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家基础科学人才培养基金(No.J1030831/J0108)资助项目

摘　　要：人类基因组转录本长度>200 nt(核苷酸)、不编码蛋白质的RNA分子为长链非编码RNA(long non-coding RNA,lncRNA)。lncRNA可在多个层面调节基因表达,其功能失调与包括肿瘤在内的很多人类疾病密切相关。本文概述lncRNA的种类、功能与疾病的关系,讨论基于lncRNA基因编辑、干细胞修饰及其与miRNA、蛋白质相互作用等的治疗潜能。Long non-coding RNAs（ lncRNAs） are a class of noncoding transcripts with lengths longer than 200 nucleotides lacking of protein-coding capability in human genome. LncRNAs can regulate gene expression at multiple levels,including chromosome remodeling,transcription and post-transcriptional processing. In addition,dysregulation of lncRNAs plays an important role in many human diseases,including cancer. Here,we reviewed the categories,functions of lncRNAs and the relation with diseases,and discussed the therapeutic strategy of lncRNA in clinic application based on gene editing,stem cell modification and the interaction between lncRNA,miRNA and protein.

关 键 词：长链非编码RNA 表观调控 功能 治疗策略 肿瘤 

分 类 号：Q75[生物学—分子生物学]