Animal models for the study of hepatitis B virus infection  

作　　者：wei-na guo bin zhu ling ai dong-liang yang bao-ju wang 

机构地区：[1]department of infectious diseases,union hospital,tongji medical college,huazhong university of science and technology,Wuhan Hubei 430022,China

出　　处：《Zoological Research》2018年第1期25-31,共7页动物学研究（英文）

基　　金：supported by the Chinese National Key Technology R&D Program(2015BAI09B06);the National Science and Technology Major Project for Infectious Diseases of China(2012ZX10004503,2017ZX10304402-002-005);the National Natural Science Foundation of China(81461130019)

摘　　要：Even with an effective vaccine, an estimated 240 million people are chronically infected with hepatitis B virus （HBV） worldwide. Current antiviral therapies, including interferon and nucleot（s）ide analogues, rarely cure chronic hepatitis B. Animal models are very crucial for understanding the pathogenesis of chronic hepatitis B and developing new therapeutic drugs or strategies. HBV can only infect humans and chimpanzees, with the use of chimpanzees in HBV research strongly restricted. Thus, most advances in HBV research have been gained using mouse models with HBV replication or infection or models with HBV-related hepadnaviral infection. This review summarizes the animal models currently available for the study of HBV infection.Even with an effective vaccine, an estimated 240 million people are chronically infected with hepatitis B virus （HBV） worldwide. Current antiviral therapies, including interferon and nucleot（s）ide analogues, rarely cure chronic hepatitis B. Animal models are very crucial for understanding the pathogenesis of chronic hepatitis B and developing new therapeutic drugs or strategies. HBV can only infect humans and chimpanzees, with the use of chimpanzees in HBV research strongly restricted. Thus, most advances in HBV research have been gained using mouse models with HBV replication or infection or models with HBV-related hepadnaviral infection. This review summarizes the animal models currently available for the study of HBV infection.

关 键 词：Hepatitis B virus Animal model Duckhepatitis B virus Woodchuck hepatitis virus 

分 类 号：Q[生物学]