侧支动脉生成的机制  

Mechanism of collateral artery growth

作　　者：管骏涛 陆晓[1] 

机构地区：[1]江苏省人民医院康复医学科,江苏南京210029

出　　处：《心血管康复医学杂志》2018年第1期83-88,共6页Chinese Journal of Cardiovascular Rehabilitation Medicine

基　　金：国家自然科学基金(81472164)~~

摘　　要：促进侧支动脉生成是治疗心肌缺血以及其他缺血性疾病的重要方式。研究表明血管剪切力的增加是侧支动脉生成的早期启动因素,可以启动一系列的反应从而来促进侧支动脉的生成。本文还主要综述了侧支动脉生成过程中涉及的细胞以及化学因子,其中包括单核细胞、平滑肌细胞、单核细胞趋化因子以及成纤维细胞生长因子等在侧支动脉生成中的作用。Promoting collateral artery growth is an important way to treat myocardial ischemia and other ischemic diseases. Researches indicate that rise of shear stress of vessel is an early activator of collateral artery growth, which can trigger a series of reactions to promote co[lateraI artery growth. The present article also mainly summarized cells and chemical factors involved in process of collateral artery growth, including monocytes, smooth muscle cells, monocyte chemoattractant protein and fibroblast growth factor etc., and their roles in collateral artery growth.

关 键 词：心肌缺血 新生血管化 生理性 单核细胞 成纤维生长因子 

分 类 号：R54[医药卫生—心血管疾病]