长期戒断甲基苯丙胺依赖患者脑结构影像学改变  

Change of brain structure imaging of long-term withdrawal of methamphetamine-dependent patients

作　　者：张志学 李平[1] 樊丽丹[2] 陶芳旭 李逸宁 蒋博 刘军[2] 寇志峰[3] ZHANG Zhixue;LI Ping;FAN Lidan;TAO Fangxu;LI Yining;JIANG Bo;LIU Jun;KOU Zhifeng(Department of Radiology, First Hospital of Hunan University of Chinese Medicine, Changsha 410007, China;Department of Radiology, Second Xiangya Hospital, Central South University, Changsha 410011, China;Department of Biomedical Engineering and Radiology, School of Medicine, Wayne State University, Detroit M148201, USA)

机构地区：[1]湖南中医药大学第一附属医院放射科,长沙410007 [2]中南大学湘雅二医院放射科,长沙410011 [3]美国韦恩州立大学生物医学工程与放射学科,美国密歇根底特律48201

出　　处：《中南大学学报（医学版）》2018年第1期41-48,共8页Journal of Central South University ：Medical Science

基　　金：湖南省科技计划项目(2015JJ4081).

摘　　要：目的:了解长期戒断甲基苯丙胺依赖患者的脑结构特点。方法:招募44名长期戒断甲基苯丙胺依赖患者(戒断时间大于14个月)及40名健康对照作为研究对象,在年龄、受教育程度、吸烟、饮酒方面进行匹配,使用西门子3.0T skyra头部正交线圈行结构功能磁共振研究;采用自制量表了解受试者基本情况和毒品使用情况,获取三维脑结构图像,然后采用基于体素的形态学分析法进行数据分析,行双样本t检验(cluster size>20,P<0.001,未校正)获得两组间差异性脑灰质区域。结果:与健康对照组比较,长期戒断甲基苯丙胺依赖患者双侧小脑脚、左侧颞上回、右侧枕叶舌回灰质体积增加,双侧距状裂周围皮质、双侧楔叶灰质体积缩小,其中左侧楔叶、左侧小脑脚灰质体积与戒断时间成正相关。结论:滥用甲基苯丙胺患者经过长期戒断后脑灰质结构仍存在异常,但是部分行为认知功能可随戒断时间延长得到改善。Objective： To explore the characteristics of brain structure in patients with long-term withdrawal of methamphetamine-dependence. Methods： A total of 44 patients with withdrawal of methamphetamine-dependent for more than 14 months were recruited, who met the diagnostic criteria for substance dependence in the fifth edition of the American Mental Disorders Diagnostic and Statistical Manual （DSM-V）, and 40 healthy subjects were used as the control. In addition to the general scale of drug-relevant survey, the subjects received the 3.0T magnetic resonance high-resolution scan. The voxel-based morphometric measurements for the subject＇s brain gray volume were conducted. Results： There was no significant difference in age, education, smoking and alcohol consumption between the methamphetamine-dependent withdrawal group and the control group （P〉0.05）. The volumes for the bilateral cerebellum, the left side of temporal gyrus and the right side of the lingual gyrus in the methamphetamine-dependent withdrawal group were increased than those in the control group. The volumes for the bilateral lingual gyrus and bilateral cuneus in the methamphetamine-dependent withdrawal group were decreased than those in the control group. The volumes of left of cuneus and cerebellum were positively correlated with the duration of abstinence. Conclusion： After long-term abstinence, although the patients still show abnormal brain structure, their behavior and cognitive function is improved. The cerebral nerve structural is recovered from long-term abstinence.

关 键 词：长期戒断 甲基苯丙胺依赖 基于体素的形态学分析 脑灰质体积 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.64[医药卫生—诊断学]