中药多糖对巨噬细胞和树突状细胞免疫调节作用的研究进展  

Effects of Polysaccharides in Chinese Medicine on the Immunomodulator Effect of Macrophage and Dendritic Cell

作　　者：秦延军 杨树宝[1] 孙朋[1] 孙博东 张美玲[1] 王凤娇[1] 马盼盼 

机构地区：[1]吉林农业大学动物科学技术学院,吉林130118

出　　处：《中国兽药杂志》2018年第2期72-77,共6页Chinese Journal of Veterinary Drug

基　　金：国家自然科学基金项目(31372391);吉林省青年科学基金项目(20150520126JH);吉林省自然科学基金项目(2015044014)

摘　　要：中药多糖有安全、无副作用及显著的免疫刺激效应的特点,是理想的免疫调节剂。目前对中药多糖免疫调节作用的研究多集中在抗体水平、器官指数等免疫指标的影响,为了揭示中药多糖的免疫调节机制,需进一步研究中药多糖对巨噬细胞及树突状细胞的免疫调节作用,尤其是对相关信号通路的影响。研究表明,中药多糖可通过Toll样受体、蛋白激酶C(PKC)、甘露糖受体(MR)等多种信号通路激活、诱导巨噬细胞及树突状细胞的成熟,减少树突状细胞的内吞作用,增强巨噬细胞吞噬能力及T细胞增殖力,促进细胞因子的释放等多种作用对机体进行免疫调节。主要从机体在正常情况、LPS诱导的炎症条件下中药多糖对巨噬细胞及树突状细胞的免疫调节作用,及不同的化学修饰后的中药多糖免疫调节作用的改变进行综述。Polysaccharides of Chinese medicine have the characteristics of safe, no side effects and significant immune stimulating effect, which is the ideal immunomodulator. At present, the study on the immune regulatory effect of polysaccharides in Chinese medicine is focused on the effects of immune indexes such as antibody level and organ index. In order to reveal the immune regulation mechanism of polysaccharides, it is necessary to further study the immunoregulation effect of polysaccharides on macrophage and dendritic cell, especially the signal pathway. Studies have shown that traditional Chinese medicine polysaccharides are able to induce macrophage and dendritic cell maturation, reduce the endocytosis of dendritic cells , enhance macrophage phagocytosis and T cellproliferation, and promote the release of cytokines through the activate of the Toll-like receptor（TLR） different signaling pathway to take effect. In this and so on. And polysaccharides of Chinese medicine may , protein kinase C （PKC）, mannose receptor（MR） and other paper, we mainly reviewed the immunoregulation effects of polysaccharides from traditional Chinese medicine on macrophage and dendritic cell in the condition of the body is healthy or under the inflammatory situation induced by LPS and when the polysaccharides under different chemical modifications.

关 键 词：中药多糖 巨噬细胞 树突状细胞 信号通路 免疫调节 

分 类 号：S853.7[农业科学—临床兽医学]