ADAMTS_13与hs_CRP水平在急性心肌梗死患者经皮冠状动脉介入术后无复流现象的相关性研究  

Correlation of ADAMTS_13 and hs_CRP levels with No_Reflow Phenonmenon in Patients with Acute Myocardial Infarction after Percutaneous Coronary Intervention

作　　者：王东[1] 刘发俊[1] 

机构地区：[1]陕西省安康市中心医院心内科,725000

出　　处：《心脑血管病防治》2018年第1期7-9,共3页CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT

摘　　要：目的探讨血管性血友因子裂解酶(ADAMTS_13)与高敏C_反应蛋白(hs_CRP)水平在急性心肌梗死患者经皮冠状动脉介入术(PCI)后无复流现象的相关性。方法选取580例急性心肌梗死患者,按照PCI后有无复流现象分为无复流组(n=150)和复流组(n=430)。PCI术前0.5h,术后即刻、术后0.5h、术后1h、术后2h及术后半年分别检测两组患者的ADAMTS_13与hs_CRP水平,探讨其相关性。结果 (1)术后即刻、0.5h、1h及2h无复流组患者hs_CRP水平明显高于复流组患者,差异有统计学意义(均P<0.05)。(2)术后即刻、0.5h及1h无复流组患者ADAMTS_13水平明显低于复流组患者,差异有统计学意义(均P<0.05)。(3)术后即刻、0.5h及1h的hs_CRP和ADAMTS_13水平呈负相关(r=-0.26、-0.57、-0.44,均P<0.05)。结论急性心肌梗死患者PCI术后无复流者早期hs_CRP水平升高且ADAMTS_13水平降低。Objective To investigate the correlation of ADAMTS-13 and hs-CRP levels with no-reflow phenomenon in patients with a- cute myocardial infarction after percutaneous coronary intervention. Methods 580 patients with acute myocardial infarction were divid- ed into no-reflow group （n = 150 cases） and reflow group （n = 430 cases） according to the coronary flow after PCI. The levels of ADAMTS-13 and hs-CRP were measured respectively at 0.Sh before the PCI, immediately, and at 0.Sh, lh, 2h and 6 months after operation. The correlation between the indexes of both groups was discussed. Results （ 1 ） The levels of hs-CRP in the no-reflow group were significantly higher than those in the reflow group immediately, at 0.5h, lh and 2h after PCI. The differences were statis- tically significant （all P 〈 0.05）. （2） The levels of ADAMTS-13 in the no-reflow group were significantly lower than those in the re- flow group immediately , at 0.Sh and lh after PCI （all P 〈 0.05）. （3） There was a negative correlation between hs-CRP and ADAM]S-13 levels immediately, at 0.5h and lh after PCI （r = - 0.26, - 0.57, - 0.44, all P 〈 0.05）. Conclusions In acute myocardial infarction patients with no-reflow after PCI, hs-CRP levels were increased and ADAMTS-13 levels were decreased in early period after percutaneous coronary intervention.

关 键 词：急性心肌梗死 经皮冠状动脉介入 高敏C反应蛋白 血管性血友因子裂解酶 无复流 

分 类 号：R542.2[医药卫生—心血管疾病] R815[医药卫生—内科学]