辅助生殖技术治疗后单胎出生低体重儿风险性研究  

Study on the risk of low birth weight in singletons conceived through assisted reproductive technology

作　　者：李静[1] 毛宝宏[1] 李亚梅[1] 王燕侠[1] 裴建赢 陈雪[1] 

机构地区：[1]甘肃省妇幼保健院,甘肃兰州730050

出　　处：《中国妇幼保健》2018年第2期391-394,共4页Maternal and Child Health Care of China

基　　金：甘肃省卫生厅行业计划课题(GSWST2013-04)

摘　　要：目的评估不同辅助生殖技术对新生儿发生出生低体重的风险性。方法根据甘肃省妇幼保健院2010-2011年的出生队列,选取5 511例正常体重儿和443例出生低体重儿行病例对照研究。结果与自然受孕相比,母亲通过IVF助孕分娩出生低体重儿的有较高风险(OR=1.75,95%CI:1.15~2.66);而通过卵泡浆内单精子显微注射(ICSI)技术会降低出生该风险(OR=0.55,95%CI:0.33~0.91);其他辅助生殖技术未发现显著相关性。结论 IVF-ET技术可以增加新生儿出生低体重的风险性,因此,对该类婴儿因加以特别的关注。Objective To evaluate the risk of low birth weight among neonates conceived through different kinds of assisted reproductive technology（ART）.Methods A total of 5 511 neonates with normal birth weight and 443 neonates with low birth weight born in Gansu Provincial Maternal and Child Health Care Hospital from 2010 to 2011 were selected,then a case-control study was performed.Results Compared with the neonates conceived naturally,the risk of low birth weight among neonates conceived through in vitro fertilization（IVF） was higher（OR=1.75,95% CI：1.15-2.66）.Intracytoplasmic sperm injection（ICSI） could reduce the risk（OR = 0.55,95%CI：0.33-0.91）.The correlation with other kinds of ART was not found.Conclusion IVF-ET can increase the risk of low birth weight among neonates,so these neonates should be paid more attention to.

关 键 词：辅助生殖技术 出生低体重 体外受精-胚胎移植 婴儿 单胎 

分 类 号：R722.19[医药卫生—儿科]