依托孕烯皮下植入后副反应观察及与外周血激素、炎症因子的关系分析  

Analysis of the relationship between the side effects of subcutaneous implantation of progesterone and peripheral blood hormones or inflammatory factors

作　　者：李长虹 肖海 于潇 LI Changhong;XIAO Hai;YU Xiao(Juxian People＇s Hospital of Shandong Province, Shandong, 27650)

机构地区：[1]山东省莒县人民医院,276500

出　　处：《中国计划生育学杂志》2018年第2期122-125,129,共5页Chinese Journal of Family Planning

摘　　要：目的:分析依托孕烯皮下植入后主要副反应及与外周血激素、炎症因子的关系。方法:对105例使用依托孕烯皮下植入后妇女随访,记录主要副反应,检测放置前后不同时间外周血雌二醇(E2)、睾酮(T)、白细胞介素-2(IL-2)和肿瘤坏死因子(TNF?α)水平。结果:放置后妇女主要副反应为阴道出血模式改变和面部痤疮,埋植后3、6、12个月均有不同出血模式改变者,其外周血E2降低,T、IL-2和TNF?α增高(P<0.05);该原因影响了妇女继续使用。结论:阴道出血模式改变和面部痤疮为依托孕烯皮下植入的主要副反应,影响了妇女的继续使用,故应加强术前的咨询服务,提高妇女使用的依从性;开展相关机理研究,减少副反应的发生及有效治疗措施。Objective：To investigate the relationship between the side effects of subcutaneous implantation of progesterone and peripheral blood hormones or inflammatory factors.Methods：105 patients underwent subcutaneous implantation of progesterone were followed up.The main side effects of subcutaneous implantation of progesterone were observed.The levels of estradiol（E2）,testosterone（T）,testosterone（T）,Interleukin-2（IL-2）and tumor necrosis factor alpha（TNF？α）were detected before and after implanted.Results：The main side effects were changes of vaginal bleeding pattern and facial acne.In the first 90 days and the second 90 days,peripheral blood E2 of patients with different bleeding patterns had significantly reduced（P〈0.05）,T,IL-2 And TNF？αhad significantly increased（P 〈0.05）.Conclusion：Changes of vaginal bleeding patterns and facial acne are primary side effects of progesterone subcutaneous implantation,which effects the use of progesterone subcutaneous implantation continually.So the pre-operative counseling service should be strengthened,and the compliance of women’s use should be improved.Relevant mechanism research should be conducted for reducing the occurrence of side reaction and developing an effective treatment.

关 键 词：依托孕烯皮下植入 阴道出血 副反应 炎症因子 性激素 

分 类 号：R169.41[医药卫生—公共卫生与预防医学]