五神针结合肾气汤加减治疗肾精亏虚型血管性痴呆临床观察  

Acupuncture at five mind points combined with modified kidney qi decoction for vascular dementia of kidney essence deficiency

作　　者：王飞[1] 王民集[2] 

机构地区：[1]河南中医药大学针灸推拿学院,郑州450008 [2]河南中医药大学第三附属医院针灸科,郑州450003

出　　处：《中国针灸》2018年第2期127-131,共5页Chinese Acupuncture & Moxibustion

基　　金：河南省重点科技攻关计划项目:09210230181

摘　　要：目的:比较五神针结合肾气汤加减与单纯五神针或肾气汤加减治疗肾精亏虚型血管性痴呆(VD)的疗效差异。方法:180例肾精亏虚型VD患者被随机分为针药结合组、五神针组和中药组,每组60例。各组均采用常规西医与康复训练治疗,在此基础上,中药组给予肾气汤加减,五神针组给予针刺百会和四神聪,针药结合组同时给予肾气汤加减联合针刺百会和四神聪,针刺每天2次,5 d为一疗程,共治疗7个疗程。比较各组治疗前后长谷川式痴呆量表(HDS)、痴呆通用筛查量表(BSSD)和简易精神状态检查表(MMSE)评分情况;检测各组治疗前后血清超氧化物歧化酶(SOD)、血清降钙素相关肽(CGRP)和过氧化脂质(LPO)的变化情况,并评定各组临床疗效。结果:针药结合组总有效率为91.7%(55/60),高于中药组的68.3%(41/60)和五神针组的78.3%(47/60),差异有统计学意义(P<0.05);各组治疗后HDS、BSSD和MMSE评分均较治疗前明显升高(均P<0.05),且针药结合组各项评分均高于中药组和五神针组(均P<0.05);各组治疗后血清SOD、CGRP水平均明显升高,LPO水平明显降低(均P<0.05);针药结合组治疗后血清SOD、CGRP水平明显高于中药组和五神针组,LPO水平低于中药组和五神针组(均P<0.05)。结论:五神针结合肾气汤加减治疗肾精亏虚型血管性痴呆疗效优于单纯五神针或肾气汤加减治疗。Objective To observe the effects for vascular dementia（VD） of kidney essence deficiency among acupuncture at five mind points combined with modified kidney qi decoction, simple acupuncture at five mind points and simple modified kidney qi decoction. Methods A total of 180 VD patients were randomly assigned into a combination group,an acupuncture group and a herb group, 60 cases in each one. The conventional western medication and rehabilitation training were for all the patients. The modified kidney qi decoction was used in the herb group; acupuncture at Baihui（GV 20） and Sishencong（EX-HN 1） was applied in the acupuncture group; the above two methods were for the cases in the combination group. Acupuncture was used for 7 courses, twice a day, and 5 days as a course. The hasegawa dementia scale（HDS）, the brief screening scale for dementia（BSSD） and the mini-mental state examination（MMSE） were applied before and after treatment. The serum superoxide dismutase（SOD）, calcitonin gene-related peptide（CGRP） and lipid peroxidation（LPO） were detected before and after treatment. The effects were evaluated. Results The total effective rate of the combination group was 91.7%（55/60）, which was better than 68.3%（41/60） in the herb group and 78.3%（47/60） in the acupuncture group（both P0.05）. After treatment, the scores of HDS, BSSD and MMSE were higher than those before treatment in the three groups（all P0.05）, and the scores in the combination group were superior to those in the other two groups（all P0.05）. SOD and CGRP increased and LPO decreased after treatment in the three groups（all P0.05）, and the results in the combination group were better（all P0.05）. Conclusion Acupuncture at five mind points combined with modified kidney qi decoction for VD is better than simple five mind acupuncture and simple modified kidney qi decoction.

关 键 词：血管性痴呆 五神针 肾气汤加减 肾精亏虚 

分 类 号：R246.6[医药卫生—针灸推拿学]