内科住院病人发生静脉血栓栓塞症危险因素的Meta分析  

Risk factors of venous thromboembolism in Chinese hospitalized patients:a meta-analysis

作　　者：秦霞 田利[1] 李惠玲[1] 胡雁[2] 曹芬[1] 张彦[1] 

机构地区：[1]苏州大学附属第一医院,江苏苏州215006 [2]复旦大学护理学院,上海200032

出　　处：《现代预防医学》2018年第4期753-756,共4页Modern Preventive Medicine

基　　金：苏州市科技局产业技术创新专项(SS201629)

摘　　要：目的分析国内内科住院病人发生静脉血栓栓塞症(VTE)的主要危险因素,为VTE的防治决策提供参考依据。方法利用Meta分析方法对国内外公开发表的关于中国内科住院病人发生VTE危险因素病例对照研究的6篇文献进行定量综合分析,共纳入病例923例,对照1 230例。结果各因素合并OR值及95%CI分别为:需要卧床>72 h OR=2.69(1.69~4.30);中心静脉置管OR=4.88(2.38~9.99);恶性肿瘤OR=3.09(1.16~8.25);1个月内大手术史OR=3.34(1.27~8.79);心力衰竭OR=1.66(1.25~2.19);严重的肺部疾病OR=2.52(1.82~3.50);年龄OR=1.84(1.51~2.25)。结论长期卧床、中心静脉置管、恶性肿瘤、1个月内大手术史、心力衰竭、严重的肺部疾病、年龄是国内内科住院病人发生VTE的主要危险因素。Objective The aim of this study was to analyze the main risk factors associated with venous thrombo-embolism （VTE） and provide a useful reference for the prophylaxis and treatment of VTE. Methods Seven databases were systematically reviewed from their inception to March 2017 for relevant case-control studies on risk factors of VTE. Six studies involving 3312 patients （VTE, 1312 patients; control, 2000 patients） were included in the recta-analysis. All analyses were performed using Reviewer Manager 5.3. Results The pooled odd ratio values and 95% CI for the risk factors were： patient confined to bed〉72 h OR=2.69 （1.69-4.30）; central venous access OR=4.88 （2.38-9.99）; malignancy 0R=3,09 （1.16-8.25）; prior major surgery （〈1 month） OR=3.34 （1.27-8.79）; heart failure OR=1.66 （1.25-2.19）; severe lung disease OR=2.52 （1.82-3.50）; age 0R=1.84 （1.51-2.25）. Conclusion Patient confined to bed〉72 h, central venous access, malignancy, prior major surgery （〈1 month）, heart failure, severe lung disease, age were the main risk factors of VTE in the hospitalized Chinese patients.

关 键 词：住院病人 静脉血栓栓塞 危险因素 META分析 

分 类 号：R543.6[医药卫生—心血管疾病]