扶正化纤方治疗特发性肺纤维化临床研究  

Clinical Study of Idiopathic Pulmonary Fibrosis Treated with Fuzheng Huaxian Formula

作　　者：赵国静 胡海波 韩萍 陆学超 

机构地区：[1]青岛市海慈医疗集团

出　　处：《山东中医杂志》2018年第1期22-25,共4页Shandong Journal of Traditional Chinese Medicine

基　　金：青岛市民生科技计划项目(编号:KJDZ-14-14-NSH)

摘　　要：目的：观察扶正化纤方治疗特发性肺纤维化（IPF）的活动耐力影响及可能机制。方法：以青岛市海慈医疗集团肺病科门诊证属气阴两虚、痰瘀阻肺证的IPF患者为研究对象,将患者随机分为对照组及观察组各30例,观察组以扶正化纤方治疗,对照组以乙酰半胱氨酸治疗,疗程3个月,观察两组患者中医证候评分、肺功能、6 min步行实验（6MWT）、圣乔治呼吸问卷（SGRQ）的变化。结果：治疗后观察组6MWT、SGRQ明显改善,与对照组相比差异有统计学意义（P〈0.05）;观察组中医证候疗效与对照组相比差异有统计学意义（P〈0.05）;但是两组患者的肺功能改善情况相比,差异无统计学意义（P〉0.05）。结论：扶正化纤方能改善患者活动耐力及生存质量,且效果优于乙酰半胱氨酸,但对肺功能无明显影响。Objective：To observe the clinical efficacy of Fuzheng Huaxian formula on idiopathic pulmonary fibrosis（IPF）. Methods：Patients diagnosed as IPF of qi and yin deficiency or phlegm and stasis blocking lung in the pulmonary clinic of Hiser Medical Group were randomly divided into control group and observation group,with 30 cases in each group. The observation group was treated with Fuzheng Huaxian formula,while the observation group was treated with acetylcysteine. After 3 months treatment,patients were observed on changes in traditional Chinese medicine（TCM） syndrome score,pulmonary function,6-minute walk test（6 MWT）,St. George＇s respiratory questionnaire（SGRQ）. Results：After the treatment,compared with the control group,the observation group showed improved 6 MWT and SGRQ scores（P〈0.05）;also the observation group showed better clinical efficacy on TCM symptom scores than the control group（P〈0.05）. However,there was no difference on the improvement of pulmonary functions between the two groups（P〈0.05）. Conclusion：Fuzheng Huaxian formula can improve the activity endurance and life quality of patients with IPF,with better effect than the acetylcysteine,but has no obvious effect on pulmonary function.

关 键 词：扶正化纤方 特发性肺纤维化 活动耐力 生存质量 

分 类 号：R256.1[医药卫生—中医内科学]