Wnt信号通路与人类疾病相关性的研究进展  

Progress in study on relationship between Wnt signaling pathway and human diseases

作　　者：张遥[1,2] 任秀智[3] 韩金祥[1,2] 鲁艳芹[1,2] 

机构地区：[1]山东省罕少见病重点实验室山东省医药生物技术研究中心山东省医学科学院,山东济南250062 [2]济南大学-山东省医学科学院医学与生命科学学院,山东济南250200 [3]天津市武清区人民医院,天津301700

出　　处：《中国生物制品学杂志》2018年第1期81-86,共6页Chinese Journal of Biologicals

基　　金：山东省英才基金项目(2015ZRC03171);山东省国际科技合作项目资助

摘　　要：Wnt信号传导通路是一条广泛存在于多细胞生物体内且具有高度进化保守性的信号通路。该通路对细胞增殖、分化、凋亡、细胞极性及细胞的迁移和侵入产生影响,在多种器官的发育形成过程以及成体状态下病理生理过程中发挥重要作用。目前已有大量研究表明,Wnt信号通路的改变与肿瘤的形成和发生、退行性疾病的发展以及干细胞功能的改变密切相关。有更多新的研究表明,该通路与炎症发生、新生血管形成、免疫功能的维持以及创伤愈合和组织再生也有潜在性的联系。该通路正作为一个关键热点应用于上述各个领域的基础应用及药物开发研究中。本文在检索Pub Med上关于Wnt信号通路与人类疾病文献的基础上,从Wnt信号通路的组成及其与人类纤维化疾病、代谢综合征、眼部疾病、肿瘤和骨相关疾病等方面的相关性,阐明Wnt信号传导通路在细胞的增殖、分化、凋亡等过程中发挥的重要调节作用及对维持诸多器官的正常发育和形成所起的至关重要的作用。Wnt signaling pathway widely exists in multi cellular organisms, with a highly evolutionary conservation, which influences the proliferation, differentiation, apoptosis, polarity, migration and invasion of cells. Wnt signaling pathways play an important role in the development of various organs as well as the formation of a variety of physiological and pathological processes. At present, a large number of studies have indicated that the change of Wnt signaling pathway is closely related to the development of tumor, degenerative diseases and the changes of stem cell function. And more new researches suggest that this pathway is associated with inflammation, angiogenesis, maintenance of immune function,potential for wound healing and tissue regeneration. This pathway is being used as a key focus in the field of basic application and drug development. Based on the literatures on Wnt signal pathways and human diseases in Pub Med existing, this paper clarifies that the Wnt signal pathway plays a vital role in maintaining the normal development and formation of various organs through the composition of the Wnt signaling pathway as well as its relationship to human diseases such as fibrotic diseases, metabolic syndrome, ocular diseases, tumor and bone-related diseases.

关 键 词：WNT信号通路 纤维化疾病 代谢综合征 肿瘤 骨相关疾病 

分 类 号：Q28[生物学—细胞生物学]