调肝理脾方治疗小儿腹泻型肠易激综合征的疗效观察及其对CGRP、NPY和VIP水平的影响  

Clinical Observation on Curative Effect of Irritable Bowel Syndrome in Children Treated with Tiaogan Lipi Fang(调肝理脾方) and Serum CGRP,NPY and VIP Levels

作　　者：吴轶颖 

机构地区：[1]衢州市中医医院儿科,浙江衢州324002

出　　处：《中国中医药科技》2018年第1期17-20,共4页Chinese Journal of Traditional Medical Science and Technology

基　　金：浙江省自然科学基金项目(LY12H16015)

摘　　要：目的:观察调肝理脾方治疗小儿腹泻型肠易激综合征的临床疗效及其对血清降钙素基因相关肽(CGRP)、神经肽(NPY)及血管活性肠肽(VIP)的影响。方法:94例小儿腹泻型肠易激综合征患儿随机分为对照组和观察组,对照组给予常规治疗,观察组在对照组基础上加以调肝理脾方治疗,2组均以7 d为1个疗程,持续治疗4个疗程。治疗结束后观察2组患儿临床疗效及不良反应,检测血清CGRP、NPY、VIP水平。结果:观察组临床总有效率为93.6%,明显高于对照组的74.8%;治疗后,2组患儿的主、次症状评分均较治疗前降低(均P<0.05),观察组低于对照组(均P<0.05)。治疗后,2组患儿血清CGRP、NPY、VIP均较治疗前改善(均P<0.05),观察组明显优于对照组(均P<0.05),2组患儿用药期间均未见明显不良反应。结论:调肝理脾方治疗小儿腹泻型肠易激综合征安全有效,改善胃肠激素水平。Objective： To observe the curative effect of irritable bowel syndrome （IBS） in children treated with Tiaogan Lipi Fang. Methods ： 94 Cases of IBS in children were randomly divided into control group and ob- servation group, 47 cases in each group. The routine treatment was given the control group, and Tiaogan Lipi Fang was given the observation group on the basis of the control group, all children were treated, one treatment course of 7 days, 4 courses of treatment continuously. The clinical efficacy and adverse reactions of the 2 groups were observed after treatment, and the levels of serum calcitonin gene -related peptide （CGRP）, neuropeptide （NPY） and vasoactive intestinal peptide （VIP） were detected. Results： The total effective rate was 93.6% in the observation group, which was better than that in the control group（74. 8% ）. The primary and secondary symptom scores of all children after treating were lower than those before treatment （P 〈 O. 05 ）, the scores in the observation group were significantly lower than those in the control group （ P 〈 0. 05 ） ; after treatment, the levels of serum CGRP, NPY and VIP in the 2 groups were improved, which were significantly better in the observation group than the control group （P 〈 0. 05 ）, all children had no obvious adverse reaction during the treatment. Conclusion： Tiaogan Lipi Fang can effectively and safely treat irritable bowel syndrome （IBS）in chil- dren, improve the level of gastrointestinal hormone.

关 键 词：调肝理脾方 肠易激综合征 血清降钙素基因相关肽(CGRP) 神经肽(NPY) 血管活性肠肽(VIP) 儿童 

分 类 号：R272[医药卫生—中医儿科学]