我院药品不良事件中超说明书用药分析  

Analysis of off-label drug uses in adverse drug events of our hospital

作　　者：李冬[1] 刘阳[2] 杨靖 胡辉[1] 

机构地区：[1]解放军第474医院药剂科,新疆乌鲁木齐830013 [2]新疆师范大学教育科学学院,新疆乌鲁木齐830054

出　　处：《中国药物应用与监测》2018年第1期46-49,共4页Chinese Journal of Drug Application and Monitoring

基　　金：2014年度全军医学科技青年培育项目(14QNP024)

摘　　要：目的:了解药品不良事件(ADE)中超说明书用药的情况,为临床合理用药提供参考。方法:回顾性分析我院2010年1月–2017年6月期间上报的1008例ADE报告,分析超说明书用药的情况。结果:1008例ADE报告中,超说明书用药228例(22.62%),其中中成药95例,抗菌药物62例,其他药物共计71例。超说明书用药的类型主要包括超适应证、超剂量、超给药途径等,其中以超适应证用药发生率最高(P<0.05)。结论:需加强监管超说明书用药现象,促进临床合理用药。Objective： To investigate the situation of off-label drug use in adverse drug event （ADE）, and provide references for rational drug use in clinic. Methods： A retrospective analysis was conducted on 1008 cases of ADE reported in our hospital from January 2010 to June 2017, and the situation of off-label drug use was analyzed. Results： In the 1008 ADE reports, 228 reports involved off-label drug use （22.62%）, including 95 cases of utilization of Chinese patent drug, 62 cases of antibacterials, 71 cases of other drugs. The main types included no-indication medication, overdose, over the normal routes of administration, and so on. Incidence of no-indication medication was the highest （P 〈 0.05）. Conclusion： It is important to tighten monitoring on the off-label drug uses for promoting clinical rational drug uses.

关 键 词：超说明书用药 药品不良事件 分析 

分 类 号：R969.3[医药卫生—药理学]