注射用单唾液酸四己糖神经节苷脂钠致格林-巴利综合征1例  

One case of Guillain-Barre syndrome caused by monosialotetrahexosylganglioside sodium for injection

作　　者：尹航[1] 于倩[1] 邵丹[1] 

机构地区：[1]吉林大学中日联谊医院药学部,吉林长春130033

出　　处：《中国药物应用与监测》2018年第1期64-66,共3页Chinese Journal of Drug Application and Monitoring

基　　金：吉林省食品药品安全监测中心项目[(2015)科技字(474)号]

摘　　要：1例50岁男性患者,既往体健,因脑外伤入院,诊断为"慢性硬膜下血肿"。入院后给予止血、抑酸、抗炎、营养神经、增强免疫药物治疗。8 d后在静脉滴注单唾液酸四己糖神经节苷脂钠(100 mg,ivgtt,qd)时出现胸闷、呼吸困难、寒战、高热,第10天逐渐出现四肢无力,第11天四肢无力加重伴呼吸困难,诊断为格林-巴利综合征,考虑为静脉滴注单唾液酸四己糖神经节苷脂钠所致,给予停用单唾液酸四己糖神经节苷脂钠,同时给予人免疫球蛋白注射液(35 g×4 d,ivgtt,qd),注射用甲泼尼龙琥珀酸钠(100 mg×14 d,60 mg×2 d,40 mg×2 d;ivgtt,qd),辅助康复训练治疗,遗留严重四肢运动功能障碍,间断呼吸机辅助呼吸。A 50-year-old male patient with a healthy history was admitted to hospital for brain trauma and was diagnosed as chronic subdural hematoma. The patient was treated with hemostasis, acid suppression, anti-infammation, nourishing nerves, enhancing immune after admission. Eight days later, chest tightness, dyspnea, chills and fever occurred when intravenous infusion of monosialotetrahexosylganglioside sodium （100 mg, ivgtt, qd） was given. On 10th day, limbs weakness appeared gradually. On 11th day, limbs weakness aggravated, accompanying with dyspnea. Clinical diagnosis was Guillain-Barre syndrome. Monosialotetrahexosylganglioside sodium was considered as suspected drug and stopped. The human immunoglobulin （35 g × 4 d, ivgtt, qd） and methylprednisolone sodium succinate （100 mg × 14 d, 60 mg × 2 d, 40 mg × 2 d, ivgtt, qd） were given to the patient, with assisting rehabilitation training. So far, severe limb movement dysfunction had been inherited, and ventilator assisted breathing was used every now and then.

关 键 词：药品不良反应 注射用单唾液酸四己糖神经节苷脂钠 格林-巴利综合征 

分 类 号：R969.3[医药卫生—药理学]