弱激光血管外照射降低血压、血脂和血糖的疗效  

Effect of Extravascular Irradiation with Weak Laser on Treating Hypertension,Hyperglycemia,and Hyperlipidemia

作　　者：阴慧娟[1] 陈珠英[1] 李迎新[1] 王增武[2] 郭新峰[3] 吴小光 

机构地区：[1]中国医学科学院北京协和医学院生物医学工程研究所激光医学实验室,天津300192 [2]中国医学科学院北京协和医学院阜外心血管医院心血管内科,北京100037 [3]广东省中医院中医循证医学团队,广州510120 [4]正安(北京)医疗设备有限公司,北京100007

出　　处：《中国医学科学院学报》2018年第1期83-90,共8页Acta Academiae Medicinae Sinicae

摘　　要：目的评估弱激光血管外照射降低血压、血脂和血糖的疗效。方法采用问卷调查方法,采集全国腕带式弱激光仪使用者的治疗信息,分析用户治疗前后的血压、血脂和血糖变化情况,采用单因素与多重线性回归方法分析弱激光照射降压的影响因素。结果共回收问卷5801份,因缺失值较多,仅将有治疗前后对比数据的调查对象纳入分析,其中,高血压1335例,高血糖180例,血脂异常129例。治疗后仪器使用者的收缩压(SBP)(t=53.16,P<0.001)、舒张压(DBP)(t=34.17,P<0.001)、三酰甘油(TG)(t=7.87,P<0.001)、总胆固醇(TC)(t=8.78,P<0.001)和空腹血糖(FBG)水平(t=11.64,P<0.001)均较使用前明显下降。与基线水平相比,治疗后仪器使用者的SBP、DBP、TG、TC和FBG分别下降了23.3 mm Hg(14.50%)(1 mm Hg=0.133 k Pa)、10.6 mm Hg(11.40%)、0.86 mmol/L(28.70%)、1.11 mmol/L(18.00%)和3.64 mmol/L(34.40%)。不失眠者的DBP下降幅度明显高于失眠者(F=9.54,P=0.00),不饮酒者的DBP下降幅度明显高于饮酒者(F=5.08,P=0.02);男性TG下降幅度明显高于女性(Z=-2.48,P=0.01),有精神压力者的TG下降幅度显著高于无精神压力者(Z=-2.16,P=0.03),吸烟者TG下降幅度明显高于无吸烟用户(Z=-2.17,P=0.03)。所有使用者的中位使用时间为616 d(1~5479 d),以四分位数分为<272 d、272~698 d、699~1435 d和1437 d 4组,其SBP下降幅度分别为(-22.25±16.22)、(-21.59±15.24)、(-24.96±16.82)和(-24.66±15.88)mm Hg,差异有统计学意义(F=3.55,P=0.01)。多元线性回归分析结果显示,性别(β=-0.08,P=0.0178)和仪器使用时间(β=-0.09,P=0.0016)是SBP变化的影响因素;性别(β=-0.10,P=0.0039)、失眠(β=0.09,P=0.0015)和饮酒(β=0.10,P=0.0033)是DBP变化的影响因素。结论长时间弱激光血管外照射有降压、降脂和降糖效果。Objective To evaluate the effect of weak laser on treating hypertension,hyperglycemia,and hyperlipidemia.Methods A questionnaire-based survey was carrried out nationwide among the users of wrist-band weak laser irradiation.Changes in blood pressure,blood lipids,and blood glucose were analyzed before and after treatment.The influencial factors of antihypertensive effect of weak laser irradiation were analyzed by univariate and multivariate linear regression method.Results Questionnaire forms were returned from 5801 users,among whom 1335 patients with hypertension,180 patients with hyperglycemia,and 129 patients with hyperlipidemia entered the final analysis.After treatment,systolic blood pressure(SBP)(t=53.16,P<0.001),diastolic blood pressure(DBP)(t=34.17,P<0.001),triglycerides(TG)(t=7.87,P<0.001),total cholesterol(TC)(t=8.78,P<0.001),and fasting blood glucose(FBG)(t=11.64,P<0.001) were significantly decreased(compared with pre-treatment levels).Compared with the baseline,SBP,DBP,TG,TC and FBG fell by 23.3 mm Hg(14.50%)(1 mm Hg=0.133 k Pa),10.6 mm Hg(11.40%),0.86 mmol/L(28.70%),1.11 mmol/L(18.00%),and 3.64 mmol/L(34.40%).The decrease of DBP in patients without insomnia was significantly higher than that in insomnia patients(F=9.54,P=0.00),and the decrease of DBP in non-drinkers was significantly higher than that in drinkers(F=5.08,P=0.02).The decrease of TG was significantly higher in males than in females(Z=2.48,P=0.01),in patients with mental stress than in those without stress(Z=-2.16,P=0.03),and in smokers than non-smokers(Z=-2.17,P=0.03).The median irradation time was 616 d(1-5479 d).According to the irradiation time,the patients were further divided into four group:<272 d,272-698 d,699-1435 d,and>1437 d.The SBP declined by(-22.25±16.22),(-21.59±15.24),(-24.96±16.82),and(-24.66±15.88) mm Hg,respectively,in these four groups(F=3.55,P=0.01).Multivariate linear regression analysis showed that the influencial factors of SBP variation included gender(β=-0.08,P=0.0178) and irradiation time(β=-0.09,P=0.0016).T

关 键 词：弱激光血管外照射 高血压 高血糖 血脂异常 问卷调查 

分 类 号：R454.2[医药卫生—治疗学]